NGN1_HUMAN
ID NGN1_HUMAN Reviewed; 237 AA.
AC Q92886; Q5U0Q9; Q96HE1;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Neurogenin-1;
DE Short=NGN-1;
DE AltName: Full=Class A basic helix-loop-helix protein 6;
DE Short=bHLHa6;
DE AltName: Full=Neurogenic basic-helix-loop-helix protein;
DE AltName: Full=Neurogenic differentiation factor 3;
DE Short=NeuroD3;
GN Name=NEUROG1; Synonyms=BHLHA6, NEUROD3, NGN, NGN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8816493; DOI=10.1128/mcb.16.10.5792;
RA McCormick M.B., Tamimi R.M., Snider L., Asakura A., Bergstrom D.,
RA Tapscott S.J.;
RT "NeuroD2 and neuroD3: distinct expression patterns and transcriptional
RT activation potentials within the neuroD gene family.";
RL Mol. Cell. Biol. 16:5792-5800(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a transcriptional regulator. Involved in the
CC initiation of neuronal differentiation. Activates transcription by
CC binding to the E box (5'-CANNTG-3'). Associates with chromatin to
CC enhancer regulatory elements in genes encoding key transcriptional
CC regulators of neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- INTERACTION:
CC Q92886; P02489: CRYAA; NbExp=3; IntAct=EBI-10279647, EBI-6875961;
CC Q92886; Q14204: DYNC1H1; NbExp=3; IntAct=EBI-10279647, EBI-356015;
CC Q92886; Q92876: KLK6; NbExp=3; IntAct=EBI-10279647, EBI-2432309;
CC Q92886; Q99081-3: TCF12; NbExp=3; IntAct=EBI-10279647, EBI-11952764;
CC Q92886; P15884: TCF4; NbExp=3; IntAct=EBI-10279647, EBI-533224;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expression restricted to the embryonic nervous
CC system.
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DR EMBL; U63842; AAB37575.1; -; Genomic_DNA.
DR EMBL; BT019366; AAV38173.1; -; mRNA.
DR EMBL; CH471062; EAW62214.1; -; Genomic_DNA.
DR EMBL; BC008687; AAH08687.1; -; mRNA.
DR EMBL; BC028226; AAH28226.1; -; mRNA.
DR CCDS; CCDS4187.1; -.
DR RefSeq; NP_006152.2; NM_006161.2.
DR AlphaFoldDB; Q92886; -.
DR SMR; Q92886; -.
DR BioGRID; 110835; 16.
DR IntAct; Q92886; 8.
DR STRING; 9606.ENSP00000317580; -.
DR iPTMnet; Q92886; -.
DR PhosphoSitePlus; Q92886; -.
DR BioMuta; NEUROG1; -.
DR DMDM; 37538313; -.
DR MassIVE; Q92886; -.
DR PaxDb; Q92886; -.
DR PeptideAtlas; Q92886; -.
DR PRIDE; Q92886; -.
DR Antibodypedia; 26408; 607 antibodies from 34 providers.
DR DNASU; 4762; -.
DR Ensembl; ENST00000314744.6; ENSP00000317580.4; ENSG00000181965.6.
DR GeneID; 4762; -.
DR KEGG; hsa:4762; -.
DR MANE-Select; ENST00000314744.6; ENSP00000317580.4; NM_006161.3; NP_006152.2.
DR UCSC; uc003lax.3; human.
DR CTD; 4762; -.
DR DisGeNET; 4762; -.
DR GeneCards; NEUROG1; -.
DR HGNC; HGNC:7764; NEUROG1.
DR HPA; ENSG00000181965; Tissue enriched (brain).
DR MIM; 601726; gene.
DR neXtProt; NX_Q92886; -.
DR OpenTargets; ENSG00000181965; -.
DR PharmGKB; PA31569; -.
DR VEuPathDB; HostDB:ENSG00000181965; -.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000162170; -.
DR HOGENOM; CLU_097959_0_0_1; -.
DR InParanoid; Q92886; -.
DR OMA; FAYGPGD; -.
DR OrthoDB; 1524429at2759; -.
DR PhylomeDB; Q92886; -.
DR TreeFam; TF315153; -.
DR PathwayCommons; Q92886; -.
DR SignaLink; Q92886; -.
DR SIGNOR; Q92886; -.
DR BioGRID-ORCS; 4762; 7 hits in 1082 CRISPR screens.
DR GeneWiki; NEUROG1; -.
DR GenomeRNAi; 4762; -.
DR Pharos; Q92886; Tbio.
DR PRO; PR:Q92886; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q92886; protein.
DR Bgee; ENSG00000181965; Expressed in ganglionic eminence and 3 other tissues.
DR ExpressionAtlas; Q92886; baseline and differential.
DR Genevisible; Q92886; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0070888; F:E-box binding; IDA:CAFA.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:CAFA.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:CAFA.
DR GO; GO:0031223; P:auditory behavior; IGI:CAFA.
DR GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
DR GO; GO:0090102; P:cochlea development; IGI:CAFA.
DR GO; GO:0090103; P:cochlea morphogenesis; IGI:CAFA.
DR GO; GO:0097094; P:craniofacial suture morphogenesis; IGI:CAFA.
DR GO; GO:0010458; P:exit from mitosis; IEA:Ensembl.
DR GO; GO:0048806; P:genitalia development; IGI:CAFA.
DR GO; GO:0035112; P:genitalia morphogenesis; IGI:CAFA.
DR GO; GO:1905748; P:hard palate morphogenesis; IGI:CAFA.
DR GO; GO:0048839; P:inner ear development; IGI:CAFA.
DR GO; GO:0042472; P:inner ear morphogenesis; IGI:CAFA.
DR GO; GO:0098583; P:learned vocalization behavior; IGI:CAFA.
DR GO; GO:0071626; P:mastication; IGI:CAFA.
DR GO; GO:1901078; P:negative regulation of relaxation of muscle; IGI:CAFA.
DR GO; GO:1905747; P:negative regulation of saliva secretion; IGI:CAFA.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IGI:CAFA.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0030432; P:peristalsis; IGI:CAFA.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0031536; P:positive regulation of exit from mitosis; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0048634; P:regulation of muscle organ development; IGI:CAFA.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007356; P:thorax and anterior abdomen determination; IGI:CAFA.
DR GO; GO:0021559; P:trigeminal nerve development; IGI:CAFA.
DR GO; GO:0021650; P:vestibulocochlear nerve formation; IGI:CAFA.
DR DisProt; DP00672; -.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032653; Ngn1.
DR PANTHER; PTHR19290:SF130; PTHR19290:SF130; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..237
FT /note="Neurogenin-1"
FT /id="PRO_0000127396"
FT DOMAIN 92..144
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 35..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 51
FT /note="G -> S (in Ref. 1; AAB37575)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 237 AA; 25718 MW; E3702A0B3408D567 CRC64;
MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE
VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP
SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA
SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH
