NGN1_RAT
ID NGN1_RAT Reviewed; 244 AA.
AC P70595;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Neurogenin-1;
DE Short=NGN-1;
DE AltName: Full=Neurogenic basic-helix-loop-helix protein;
DE AltName: Full=Neurogenic differentiation factor 3;
DE Short=NeuroD3;
GN Name=Neurog1; Synonyms=Neurod3, Ngn, Ngn1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Embryo;
RX PubMed=8858147; DOI=10.1016/s0092-8674(00)81321-5;
RA Ma Q., Kintner C., Anderson D.J.;
RT "Identification of neurogenin, a vertebrate neuronal determination gene.";
RL Cell 87:43-52(1996).
CC -!- FUNCTION: Acts as a transcriptional regulator. Involved in the
CC initiation of neuronal differentiation. Activates transcription by
CC binding to the E box (5'-CANNTG-3'). Associates with chromatin to
CC enhancer regulatory elements in genes encoding key transcriptional
CC regulators of neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expression restricted to the embryonic nervous
CC system.
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DR EMBL; U67777; AAC52857.1; -; mRNA.
DR RefSeq; NP_062080.1; NM_019207.1.
DR AlphaFoldDB; P70595; -.
DR SMR; P70595; -.
DR STRING; 10116.ENSRNOP00000015916; -.
DR iPTMnet; P70595; -.
DR PhosphoSitePlus; P70595; -.
DR PaxDb; P70595; -.
DR DNASU; 29410; -.
DR Ensembl; ENSRNOT00000015916; ENSRNOP00000015916; ENSRNOG00000022405.
DR GeneID; 29410; -.
DR KEGG; rno:29410; -.
DR UCSC; RGD:3167; rat.
DR CTD; 4762; -.
DR RGD; 3167; Neurog1.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000162170; -.
DR HOGENOM; CLU_097959_0_0_1; -.
DR InParanoid; P70595; -.
DR OMA; FAYGPGD; -.
DR OrthoDB; 1524429at2759; -.
DR PhylomeDB; P70595; -.
DR TreeFam; TF315153; -.
DR PRO; PR:P70595; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Genevisible; P70595; RN.
DR GO; GO:0043025; C:neuronal cell body; ISO:RGD.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; ISO:RGD.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0031223; P:auditory behavior; ISO:RGD.
DR GO; GO:0045165; P:cell fate commitment; ISO:RGD.
DR GO; GO:0090102; P:cochlea development; ISO:RGD.
DR GO; GO:0090103; P:cochlea morphogenesis; ISO:RGD.
DR GO; GO:0097094; P:craniofacial suture morphogenesis; ISO:RGD.
DR GO; GO:0010458; P:exit from mitosis; IEA:Ensembl.
DR GO; GO:0048806; P:genitalia development; ISO:RGD.
DR GO; GO:0035112; P:genitalia morphogenesis; ISO:RGD.
DR GO; GO:1905748; P:hard palate morphogenesis; ISO:RGD.
DR GO; GO:0048839; P:inner ear development; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0098583; P:learned vocalization behavior; ISO:RGD.
DR GO; GO:0071626; P:mastication; ISO:RGD.
DR GO; GO:1901078; P:negative regulation of relaxation of muscle; ISO:RGD.
DR GO; GO:1905747; P:negative regulation of saliva secretion; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; NAS:RGD.
DR GO; GO:0022008; P:neurogenesis; ISO:RGD.
DR GO; GO:0050885; P:neuromuscular process controlling balance; ISO:RGD.
DR GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR GO; GO:0030432; P:peristalsis; ISO:RGD.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0031536; P:positive regulation of exit from mitosis; ISO:RGD.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0048634; P:regulation of muscle organ development; ISO:RGD.
DR GO; GO:0045664; P:regulation of neuron differentiation; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007356; P:thorax and anterior abdomen determination; ISO:RGD.
DR GO; GO:0021559; P:trigeminal nerve development; ISO:RGD.
DR GO; GO:0021650; P:vestibulocochlear nerve formation; ISO:RGD.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032653; Ngn1.
DR PANTHER; PTHR19290:SF130; PTHR19290:SF130; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..244
FT /note="Neurogenin-1"
FT /id="PRO_0000127398"
FT DOMAIN 93..145
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 43..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 244 AA; 26182 MW; 47D0E91403143D61 CRC64;
MPAPLETCLS DLDCASSNSG SDLSSFLTDE EDCARLQPLA STSGLSVPAR RSAPTLSGAS
NVPGGQDEEQ ERRRRRGRAR VRSEALLHSL RRSRRVKAND RERNRMHNLN AALDALRSVL
PSFPDDTKLT KIETLRFAYN YIWALAETLR LADQGLPGGG ARERLLPPQC VPCLPGPPSP
ASDTESWGSG AAASPCATVA SPLSDPSSPS ASEDFTYGPG GPLFSFPGLP KDLLHTTPCF
IPYH
