NGN2_HUMAN
ID NGN2_HUMAN Reviewed; 272 AA.
AC Q9H2A3; Q8N416;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Neurogenin-2;
DE Short=NGN-2;
DE AltName: Full=Class A basic helix-loop-helix protein 8;
DE Short=bHLHa8;
DE AltName: Full=Protein atonal homolog 4;
GN Name=NEUROG2; Synonyms=ATOH4, BHLHA8, NGN2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-272.
RA Simmons A.D., Horton S., Abney A.L., Johnson J.E.;
RT "Neurogenin 2 expression in ventral and dorsal spinal neural tube
RT progenitor cells is regulated by distinct enhancers.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator. Involved in neuronal
CC differentiation. Activates transcription by binding to the E box (5'-
CC CANNTG-3').
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9H2A3; Q99471: PFDN5; NbExp=3; IntAct=EBI-7969348, EBI-357275;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; BC036847; AAH36847.1; -; mRNA.
DR EMBL; AF303002; AAG40770.1; -; Genomic_DNA.
DR CCDS; CCDS3698.1; -.
DR RefSeq; NP_076924.1; NM_024019.3.
DR AlphaFoldDB; Q9H2A3; -.
DR SMR; Q9H2A3; -.
DR BioGRID; 122020; 3.
DR IntAct; Q9H2A3; 2.
DR MINT; Q9H2A3; -.
DR STRING; 9606.ENSP00000317333; -.
DR iPTMnet; Q9H2A3; -.
DR PhosphoSitePlus; Q9H2A3; -.
DR BioMuta; NEUROG2; -.
DR DMDM; 60392832; -.
DR MassIVE; Q9H2A3; -.
DR PaxDb; Q9H2A3; -.
DR PeptideAtlas; Q9H2A3; -.
DR PRIDE; Q9H2A3; -.
DR ProteomicsDB; 80519; -.
DR Antibodypedia; 26453; 353 antibodies from 35 providers.
DR DNASU; 63973; -.
DR Ensembl; ENST00000313341.4; ENSP00000317333.3; ENSG00000178403.4.
DR GeneID; 63973; -.
DR KEGG; hsa:63973; -.
DR MANE-Select; ENST00000313341.4; ENSP00000317333.3; NM_024019.4; NP_076924.1.
DR UCSC; uc003ias.3; human.
DR CTD; 63973; -.
DR DisGeNET; 63973; -.
DR GeneCards; NEUROG2; -.
DR HGNC; HGNC:13805; NEUROG2.
DR HPA; ENSG00000178403; Group enriched (brain, testis).
DR MIM; 606624; gene.
DR neXtProt; NX_Q9H2A3; -.
DR OpenTargets; ENSG00000178403; -.
DR PharmGKB; PA31570; -.
DR VEuPathDB; HostDB:ENSG00000178403; -.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000162895; -.
DR HOGENOM; CLU_097959_0_0_1; -.
DR InParanoid; Q9H2A3; -.
DR OMA; GLVHECK; -.
DR OrthoDB; 1524429at2759; -.
DR PhylomeDB; Q9H2A3; -.
DR TreeFam; TF315153; -.
DR PathwayCommons; Q9H2A3; -.
DR SignaLink; Q9H2A3; -.
DR SIGNOR; Q9H2A3; -.
DR BioGRID-ORCS; 63973; 15 hits in 1098 CRISPR screens.
DR GeneWiki; NEUROG2; -.
DR GenomeRNAi; 63973; -.
DR Pharos; Q9H2A3; Tbio.
DR PRO; PR:Q9H2A3; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9H2A3; protein.
DR Bgee; ENSG00000178403; Expressed in ganglionic eminence and 25 other tissues.
DR Genevisible; Q9H2A3; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032655; Ngn2.
DR PANTHER; PTHR19290:SF105; PTHR19290:SF105; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..272
FT /note="Neurogenin-2"
FT /id="PRO_0000127400"
FT DOMAIN 112..164
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 30..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 28621 MW; 57AB37CC4A9E15FC CRC64;
MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG ARRQRGAEAG
QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA KTAETVQRIK KTRRLKANNR
ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCGGGGGG
LPGALFSEAV LLSPGGASAA LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP
ASPAGSDMDY WQPPPPDKHR YAPHLPIARD CI
