ID   NGRN_BOVIN              Reviewed;         287 AA.
AC   Q2HJC0;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Neugrin;
DE   AltName: Full=Neurite outgrowth-associated protein;
DE   Flags: Precursor;
GN   Name=NGRN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in mitochondrial ribosome biogenesis.
CC       As a component of a functional protein-RNA module, consisting of RCC1L,
CC       NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal
CC       RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for
CC       intra-mitochondrial translation of core subunits of the oxidative
CC       phosphorylation system. {ECO:0000250|UniProtKB:Q9NPE2}.
CC   -!- SUBUNIT: Forms a regulatory protein-RNA complex, consisting of RCC1L,
CC       NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with
CC       16S mt-rRNA; this interaction is direct.
CC       {ECO:0000250|UniProtKB:Q9NPE2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NPE2}. Secreted
CC       {ECO:0000250|UniProtKB:Q9NPE2}. Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9NPE2}.
CC   -!- SIMILARITY: Belongs to the neugrin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI13207.1; Type=Miscellaneous discrepancy; Note=Intron retention. Includes intronic sequence at the 5' end.; Evidence={ECO:0000305};
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DR   EMBL; DV893056; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC113206; AAI13207.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001039457.2; NM_001045992.2.
DR   AlphaFoldDB; Q2HJC0; -.
DR   STRING; 9913.ENSBTAP00000019282; -.
DR   PaxDb; Q2HJC0; -.
DR   PRIDE; Q2HJC0; -.
DR   Ensembl; ENSBTAT00000019282; ENSBTAP00000019282; ENSBTAG00000014505.
DR   GeneID; 508115; -.
DR   KEGG; bta:508115; -.
DR   CTD; 51335; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014505; -.
DR   VGNC; VGNC:57159; NGRN.
DR   eggNOG; ENOG502S5A6; Eukaryota.
DR   GeneTree; ENSGT00390000014472; -.
DR   HOGENOM; CLU_076903_1_0_1; -.
DR   InParanoid; Q2HJC0; -.
DR   OMA; AMDQIRY; -.
DR   OrthoDB; 734251at2759; -.
DR   TreeFam; TF324463; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000014505; Expressed in Ammon's horn and 106 other tissues.
DR   GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0061668; P:mitochondrial ribosome assembly; ISS:UniProtKB.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR   InterPro; IPR010487; NGRN/Rrg9.
DR   PANTHER; PTHR13475; PTHR13475; 1.
DR   Pfam; PF06413; Neugrin; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Glycoprotein; Membrane;
KW   Mitochondrion; Nucleus; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..287
FT                   /note="Neugrin"
FT                   /id="PRO_0000294482"
FT   REGION          149..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        202
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  31741 MW;  B96A44843611A656 CRC64;
     MAFSPNVLLG GRVCAAVARS GFATRRVTIP GSTSREPDPD FDWEPEEREL QEVESALKRQ
     KKAIRFQKIR RQMEASGAPP RTLTWEAMEQ IRYLHREFSE SWSVPRLAEG FDVSTDVIRR
     VLKSKFIPTL EQKLKQDQKV LKKIGLARSI PELPGPGDSS KPLSAGQSVS GSLLIPGDEA
     SSRGHGHSTA LKAIELNTQS TNITTRQTER NKGVQGLEEG KDFVPVAAGH PTSTCRGARG
     IDSDGLPSDK RLEELKAGEA GDQIFSKRVV QRGREFFDSN GNFLYRI