ID   NGRN_PONAB              Reviewed;         291 AA.
AC   Q5R7E7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Neugrin;
DE   AltName: Full=Neurite outgrowth-associated protein;
DE   Flags: Precursor;
GN   Name=NGRN;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in mitochondrial ribosome biogenesis.
CC       As a component of a functional protein-RNA module, consisting of RCC1L,
CC       NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal
CC       RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for
CC       intra-mitochondrial translation of core subunits of the oxidative
CC       phosphorylation system. {ECO:0000250|UniProtKB:Q9NPE2}.
CC   -!- SUBUNIT: Forms a regulatory protein-RNA complex, consisting of RCC1L,
CC       NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with
CC       16S mt-rRNA; this interaction is direct.
CC       {ECO:0000250|UniProtKB:Q9NPE2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NPE2}. Secreted
CC       {ECO:0000250|UniProtKB:Q9NPE2}. Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9NPE2}.
CC   -!- SIMILARITY: Belongs to the neugrin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH92313.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR787252; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; CR860171; CAH92313.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001126356.1; NM_001132884.1.
DR   AlphaFoldDB; Q5R7E7; -.
DR   SMR; Q5R7E7; -.
DR   STRING; 9601.ENSPPYP00000007688; -.
DR   GeneID; 100173337; -.
DR   KEGG; pon:100173337; -.
DR   CTD; 51335; -.
DR   eggNOG; ENOG502S5A6; Eukaryota.
DR   InParanoid; Q5R7E7; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0061668; P:mitochondrial ribosome assembly; ISS:UniProtKB.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR   InterPro; IPR010487; NGRN/Rrg9.
DR   PANTHER; PTHR13475; PTHR13475; 1.
DR   Pfam; PF06413; Neugrin; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Glycoprotein; Membrane;
KW   Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..291
FT                   /note="Neugrin"
FT                   /id="PRO_0000294485"
FT   REGION          27..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          224..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NPE2"
FT   CARBOHYD        158
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   291 AA;  32588 MW;  12A873AAD1B5640C CRC64;
     MAVTLSLLLS GRVCAAVARC GFATRGVADP GPIGREPDPD SDWEPEEREL QEVKSTLKRQ
     KKAIRFQKIR RQMEASGAPP RTLTWEAMEQ IRYLHEEFPE SWSVPRLAEG FDVSTDVIRR
     VLKSKFLPTL EQKLKQDQKV LKKAGLAPLL QQLRGSGNTS KLLPAGHSVS GSLLMPGHEA
     SSKDPNHSTA LKVIESDTHR TNTPRRWKGR NKEIQDLEES FVPVAAPLGH PRELQKYSSD
     SESPRRTGNG ALPSDQKLEE LKAEEPGNFS SKVVQRGREF FDSNGNFLYR I