ID   NGRN_RAT                Reviewed;         293 AA.
AC   Q3T1H2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 3.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Neugrin;
DE   AltName: Full=Neurite outgrowth-associated protein;
DE   Flags: Precursor;
GN   Name=Ngrn;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays an essential role in mitochondrial ribosome biogenesis.
CC       As a component of a functional protein-RNA module, consisting of RCC1L,
CC       NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal
CC       RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for
CC       intra-mitochondrial translation of core subunits of the oxidative
CC       phosphorylation system. {ECO:0000250|UniProtKB:Q9NPE2}.
CC   -!- SUBUNIT: Forms a regulatory protein-RNA complex, consisting of RCC1L,
CC       NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with
CC       16S mt-rRNA; this interaction is direct.
CC       {ECO:0000250|UniProtKB:Q9NPE2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NPE2}. Secreted
CC       {ECO:0000250|UniProtKB:Q9NPE2}. Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9NPE2}.
CC   -!- SIMILARITY: Belongs to the neugrin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI01927.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC101926; AAI01927.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001029072.2; NM_001033900.2.
DR   AlphaFoldDB; Q3T1H2; -.
DR   SMR; Q3T1H2; -.
DR   STRING; 10116.ENSRNOP00000018107; -.
DR   GlyGen; Q3T1H2; 1 site.
DR   PaxDb; Q3T1H2; -.
DR   Ensembl; ENSRNOT00000018107; ENSRNOP00000018107; ENSRNOG00000013553.
DR   GeneID; 499191; -.
DR   KEGG; rno:499191; -.
DR   UCSC; RGD:1583734; rat.
DR   CTD; 51335; -.
DR   RGD; 1583734; Ngrn.
DR   eggNOG; ENOG502S5A6; Eukaryota.
DR   GeneTree; ENSGT00390000014472; -.
DR   HOGENOM; CLU_076903_1_0_1; -.
DR   InParanoid; Q3T1H2; -.
DR   OMA; AMDQIRY; -.
DR   OrthoDB; 734251at2759; -.
DR   PhylomeDB; Q3T1H2; -.
DR   TreeFam; TF324463; -.
DR   PRO; PR:Q3T1H2; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000013553; Expressed in cerebellum and 20 other tissues.
DR   Genevisible; Q3T1H2; RN.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0019843; F:rRNA binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0061668; P:mitochondrial ribosome assembly; ISS:UniProtKB.
DR   GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR   InterPro; IPR010487; NGRN/Rrg9.
DR   PANTHER; PTHR13475; PTHR13475; 1.
DR   Pfam; PF06413; Neugrin; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Glycoprotein; Membrane;
KW   Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..293
FT                   /note="Neugrin"
FT                   /id="PRO_0000294486"
FT   REGION          25..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          162..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NPE2"
FT   CARBOHYD        270
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   293 AA;  32951 MW;  708BAE4D64DD58EB CRC64;
     MALSLSLFLG GRVRAAVARC GFASQGVAGP GSISREPDPD SDWEPEEREL QEVESALKRQ
     KKAMRFQKIR RQMEAPGAPP RTLTWEAMEQ IRYLHKEFAE SWSVPRLAEG FDVSTDVIRR
     VLKSKFIPTL EQKLKQDQKV LKKAGITRVV WQLPVSEDTL KPLSAGHPMS GPLLMPGDEV
     SSNSQTHSRA LKVKSNAPSA EAQKKREEKN KRIRVLAESL VPTTTALGHQ RELQKYTTHD
     SEADRRANNH ILPSVEKLEE LEAGEPGDQN FSSKVVQKGR EFFDSNGNFL YRI