NH100_CAEEL
ID NH100_CAEEL Reviewed; 437 AA.
AC O17611;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 3.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Nuclear hormone receptor family member nhr-100;
GN Name=nhr-100; ORFNames=C28D4.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AY305849; AAR11993.1; -; mRNA.
DR EMBL; Z82259; CAB05126.3; -; Genomic_DNA.
DR PIR; T19540; T19540.
DR RefSeq; NP_501731.1; NM_069330.5.
DR AlphaFoldDB; O17611; -.
DR SMR; O17611; -.
DR BioGRID; 42910; 1.
DR IntAct; O17611; 1.
DR STRING; 6239.C28D4.1; -.
DR iPTMnet; O17611; -.
DR PaxDb; O17611; -.
DR PeptideAtlas; O17611; -.
DR EnsemblMetazoa; C28D4.1.1; C28D4.1.1; WBGene00003690.
DR EnsemblMetazoa; C28D4.1.2; C28D4.1.2; WBGene00003690.
DR GeneID; 177806; -.
DR KEGG; cel:CELE_C28D4.1; -.
DR UCSC; C28D4.1.1; c. elegans.
DR CTD; 177806; -.
DR WormBase; C28D4.1; CE28893; WBGene00003690; nhr-100.
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_3_3_1; -.
DR InParanoid; O17611; -.
DR OMA; DIAMAWQ; -.
DR OrthoDB; 1097181at2759; -.
DR PhylomeDB; O17611; -.
DR PRO; PR:O17611; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003690; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..437
FT /note="Nuclear hormone receptor family member nhr-100"
FT /id="PRO_0000223585"
FT DOMAIN 141..409
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 21..96
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 24..44
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 60..79
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 437 AA; 51142 MW; CF5B539264B0096A CRC64;
MNIPFNSVSK IQWRNPSPVS DTSCLVCGDP HGKRHYGAMS CNGCKGFFRR SIWEKRTYKC
SFNNECIIEF KYRNRCRACR LKRCLHVGMD ANAVRSERTR KIKTEIDGDV KLEIKEEPAD
SEDADDECPL DIKPDIAMAW QTKEIIAHML YEEDRVLNWE EPYNKLRYYT MDSEVLQAIK
DPSQVCARTK INWNSHSRPL ITIEALRFNW CRTFTLTIDW FETLPEYRAL IDDDKELLVK
FSLMPVGWLW YAYKSYEYRC DGIVFVDGSW FPRDKTIQQQ VCPTCVLYYG RITESFMADV
VNSMKELEMD ETEMVLLKAI CHLQPDYRLT RRGNDVISTG REKYKRALCE YIRMKSNGFM
DASFRLCKLM QILPVVDILG KYEDESALLV SLGETEFNGS GGGLPYDIHA SDSHFARKNR
RKSDNQYHQQ HVPLHIQ
