NH103_CAEEL
ID NH103_CAEEL Reviewed; 394 AA.
AC O16359;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Nuclear hormone receptor family member nhr-103;
GN Name=nhr-103; ORFNames=F44C8.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; FO081357; CCD71004.1; -; Genomic_DNA.
DR PIR; T31791; T31791.
DR RefSeq; NP_503607.1; NM_071206.1.
DR AlphaFoldDB; O16359; -.
DR SMR; O16359; -.
DR IntAct; O16359; 1.
DR STRING; 6239.F44C8.4; -.
DR PaxDb; O16359; -.
DR EnsemblMetazoa; F44C8.4.1; F44C8.4.1; WBGene00003693.
DR GeneID; 178701; -.
DR KEGG; cel:CELE_F44C8.4; -.
DR UCSC; F44C8.4; c. elegans.
DR CTD; 178701; -.
DR WormBase; F44C8.4; CE27384; WBGene00003693; nhr-103.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000195928; -.
DR HOGENOM; CLU_007368_7_1_1; -.
DR InParanoid; O16359; -.
DR OMA; CEPAKIA; -.
DR OrthoDB; 1695884at2759; -.
DR PhylomeDB; O16359; -.
DR PRO; PR:O16359; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003693; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..394
FT /note="Nuclear hormone receptor family member nhr-103"
FT /id="PRO_0000223586"
FT DOMAIN 126..394
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 8..83
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 11..31
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 47..66
FT /note="NR C4-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 394 AA; 45415 MW; F6FADFCF4708155B CRC64;
MPAPLFLSGP CEICGQKTSG RHFGVLSCRS CAAFFRRSAT WSRKKVQCVK GTCKIFEDGK
FNCKQCRLKK CVEVGMDSKK FQTNRDLISS CSVPQSLCNF LGRPEFILCC EPDKASVFKT
TIDVTYLVDM AKNLLEKDPC QCPLSNSLEQ LSTTLENMRG MKLNKETQII KKLGKNESLK
TWEQGFLRAV EWFSNFSEFR ELDENLKMEI LKTCWVSWIR LDKLSETANK RVNATLDNSL
LMVGNDSCMH MNDYEVDLSW CTNYSLEQLA FFFLTPDDEK NYRQLIQDMV DLNPSSTEIS
YMLLQLSLEH AGKRLQGDIL EATESLVQAQ ANQLHDYYAK KLKLSNYSSR LTQLMKITRT
LEADMRLRIE KKKVADVFNI FKIQFSHPEM FETT
