ID   NH106_CAEEL             Reviewed;         382 AA.
AC   O16966;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Nuclear hormone receptor family member nhr-106;
GN   Name=nhr-106; ORFNames=T01G6.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AY204190; AAO39194.1; -; mRNA.
DR   EMBL; FO081653; CCD73119.1; -; Genomic_DNA.
DR   RefSeq; NP_503219.1; NM_070818.4.
DR   AlphaFoldDB; O16966; -.
DR   SMR; O16966; -.
DR   STRING; 6239.T01G6.4; -.
DR   PaxDb; O16966; -.
DR   EnsemblMetazoa; T01G6.4.1; T01G6.4.1; WBGene00003696.
DR   GeneID; 178571; -.
DR   KEGG; cel:CELE_T01G6.4; -.
DR   UCSC; T01G6.4; c. elegans.
DR   CTD; 178571; -.
DR   WormBase; T01G6.4; CE27433; WBGene00003696; nhr-106.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000195869; -.
DR   HOGENOM; CLU_007368_7_1_1; -.
DR   InParanoid; O16966; -.
DR   OMA; HTFDIFI; -.
DR   OrthoDB; 1718864at2759; -.
DR   PhylomeDB; O16966; -.
DR   PRO; PR:O16966; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003696; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..382
FT                   /note="Nuclear hormone receptor family member nhr-106"
FT                   /id="PRO_0000223587"
FT   DOMAIN          110..380
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        2..78
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         5..25
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         42..61
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   382 AA;  43903 MW;  99C996015188D92D CRC64;
     MQTTCEICEV PAHGIHFGAI TCRGCAAFFR RAVNTKTNRK SCKYSSNCTN FTGKFPQCKS
     CRMRKCIKMG MMPEKVKVMQ PISQSLEIFV SRPNLILFTN NYDKTRNYID VSNLITRGLE
     ILKQGFPTPL GIGKTNLERM ASGVEFSTAE SKIVDVVTGK SVSMVWEFDF ISTAKWLTRL
     QDFCTLPMRI QMQLLQTIWH VWSRMYKVVK SSELRKKHAD SSNLFQVLDQ FHVNLGTTKL
     DVSWLTTYSY EEIKYFLYGI DDDIYLQSAI TAASKLELTD VELTYMAAQT CFQYAQNRFA
     GTEIAEVCAK FQEILANDLH TYYTKDHKRT SNYAGKLSQM LKCVQEIQKS IRTTRERTTI
     ARTFDIYITD FSNPEMFIDS GC