ID   NH108_CAEEL             Reviewed;         338 AA.
AC   O45449;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Nuclear hormone receptor family member nhr-108;
GN   Name=nhr-108; ORFNames=F35E8.12;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AY204193; AAO39197.1; -; mRNA.
DR   EMBL; Z81529; CAB04290.1; -; Genomic_DNA.
DR   PIR; T21784; T21784.
DR   RefSeq; NP_506987.1; NM_074586.4.
DR   AlphaFoldDB; O45449; -.
DR   SMR; O45449; -.
DR   BioGRID; 45056; 1.
DR   DIP; DIP-25366N; -.
DR   IntAct; O45449; 1.
DR   STRING; 6239.F35E8.12; -.
DR   PaxDb; O45449; -.
DR   EnsemblMetazoa; F35E8.12.1; F35E8.12.1; WBGene00003698.
DR   EnsemblMetazoa; F35E8.12.2; F35E8.12.2; WBGene00003698.
DR   GeneID; 180065; -.
DR   KEGG; cel:CELE_F35E8.12; -.
DR   UCSC; F35E8.12; c. elegans.
DR   CTD; 180065; -.
DR   WormBase; F35E8.12; CE15962; WBGene00003698; nhr-108.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000196002; -.
DR   HOGENOM; CLU_007368_1_1_1; -.
DR   InParanoid; O45449; -.
DR   OMA; SAREKTF; -.
DR   OrthoDB; 1732470at2759; -.
DR   PhylomeDB; O45449; -.
DR   PRO; PR:O45449; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003698; Expressed in adult organism and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..338
FT                   /note="Nuclear hormone receptor family member nhr-108"
FT                   /id="PRO_0000223588"
FT   DOMAIN          92..338
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        7..82
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         10..30
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         46..65
FT                   /note="NR C4-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   338 AA;  39406 MW;  381CA3F8D942294F CRC64;
     MSKKSENQPC MVCGEISYSI RFGAVSCRAC AEFFRRKIVS KARIPKRCNG ACDLGKYHRK
     TCQSCRFQKC LKIGMLEKVV ASRTPVNRRS ENNQTILSGL EKAYDKLENS RDNVFDRKNK
     IPKYCNHQEL DDMFEIDIKL ISTHFIQFFE SKSSLENNQN KVLSTHFIIR FSLLEVAFRA
     FGKPTYILPN NDIIDVSKLD KVYQHLETGE DERGKNSQVI LQRFWQMNEK TMKTEVFPVN
     LDQSEFLFLC ALIYWDFGIE NQSEKCLEEC QRMRTQVLKE LTEYEKSNYP ENELRVAQVI
     GILQALQKTL DVIQHSGYIS NVYNLKGKQC PLYEATNE