ID   NH111_CAEEL             Reviewed;         311 AA.
AC   O45521;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   03-AUG-2022, entry version 162.
DE   RecName: Full=Nuclear hormone receptor family member nhr-111;
GN   Name=nhr-111; ORFNames=F44G3.9;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- INTERACTION:
CC       O45521; O16519: gad-1; NbExp=3; IntAct=EBI-313236, EBI-327317;
CC       O45521; Q93701: gst-19; NbExp=3; IntAct=EBI-313236, EBI-321323;
CC       O45521; Q95Y97: rpa-2; NbExp=3; IntAct=EBI-313236, EBI-325404;
CC       O45521; Q9TZI2: ztf-4; NbExp=3; IntAct=EBI-313236, EBI-322494;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; Z83109; CAB05521.2; -; Genomic_DNA.
DR   PIR; T22203; T22203.
DR   RefSeq; NP_507060.2; NM_074659.2.
DR   AlphaFoldDB; O45521; -.
DR   SMR; O45521; -.
DR   BioGRID; 50516; 133.
DR   DIP; DIP-26766N; -.
DR   IntAct; O45521; 98.
DR   STRING; 6239.F44G3.9; -.
DR   PaxDb; O45521; -.
DR   EnsemblMetazoa; F44G3.9.1; F44G3.9.1; WBGene00003701.
DR   GeneID; 185757; -.
DR   KEGG; cel:CELE_F44G3.9; -.
DR   UCSC; F44G3.9; c. elegans.
DR   CTD; 185757; -.
DR   WormBase; F44G3.9; CE35538; WBGene00003701; nhr-111.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000156926; -.
DR   HOGENOM; CLU_007368_9_0_1; -.
DR   InParanoid; O45521; -.
DR   OMA; QWIRILL; -.
DR   OrthoDB; 950771at2759; -.
DR   PhylomeDB; O45521; -.
DR   SignaLink; O45521; -.
DR   PRO; PR:O45521; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003701; Expressed in embryo.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..311
FT                   /note="Nuclear hormone receptor family member nhr-111"
FT                   /id="PRO_0000223589"
FT   DOMAIN          116..311
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        39..115
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         42..62
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         78..98
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   311 AA;  35145 MW;  3F54D39BA3732AA2 CRC64;
     MSSQNAKSIG GILETSTVPL VIQPQIVNDP AQNNITLPIT LCAVCGDTSN GNHYGVPTCF
     GCSGFFRRTV RNKLVHGCWN GDGNCVIDKA NRNRCKSCRI KKCFKKGMNK NAVQPERTSH
     SYTVEYVELP SFREYSKGLL PTHSDRLRFQ HEHAQHEIDT SSVLVHLKNA LQWVQQFSLF
     AVLSDVEKSQ IILTQWPHLL CLALFENSEK IFIDEKFAQL AEKFKSLELS AQDYFLLKGI
     IIFTETKDGT DLKFDRQLDI CIGLLNQLHL ESSKSKSGRL LFLLGELKSY STRQLESLLD
     LKACEIVISF L