ID   NH115_CAEEL             Reviewed;         391 AA.
AC   O16662; Q86PI5;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 3.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Nuclear hormone receptor family member nhr-115;
GN   Name=nhr-115; ORFNames=T27B7.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AY204203; AAO39204.1; -; mRNA.
DR   EMBL; FO081753; CCD74245.1; -; Genomic_DNA.
DR   RefSeq; NP_001256014.1; NM_001269085.1.
DR   AlphaFoldDB; O16662; -.
DR   STRING; 6239.T27B7.4a; -.
DR   PaxDb; O16662; -.
DR   EnsemblMetazoa; T27B7.4a.1; T27B7.4a.1; WBGene00003705.
DR   GeneID; 178708; -.
DR   KEGG; cel:CELE_T27B7.4; -.
DR   UCSC; T27B7.4.1; c. elegans.
DR   CTD; 178708; -.
DR   WormBase; T27B7.4a; CE35785; WBGene00003705; nhr-115.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000195869; -.
DR   HOGENOM; CLU_007368_7_1_1; -.
DR   InParanoid; O16662; -.
DR   OMA; FMDIIEY; -.
DR   OrthoDB; 1689175at2759; -.
DR   PhylomeDB; O16662; -.
DR   PRO; PR:O16662; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003705; Expressed in adult organism and 2 other tissues.
DR   ExpressionAtlas; O16662; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..391
FT                   /note="Nuclear hormone receptor family member nhr-115"
FT                   /id="PRO_0000053803"
FT   DOMAIN          130..388
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        5..77
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         8..28
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         41..65
FT                   /note="NR C4-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   391 AA;  46289 MW;  EA49D350BCBCA3D8 CRC64;
     MKKVLFPCQI CGQNSHGTHF GIVSCRACAA FFRRSVNSKW ARKGCLTNFK DKGSCFCKPC
     RLRKCVEIGM DASKFQYDRD AISAIKHPKI FPSVSYYVGR PEFLMFSDSN VTSQKTFIDV
     QNLVFEVSRY LDHGCETPIY AENQLKKLTL GFKLMQFDYQ NVKFFDKIGK AEFIDIIEYY
     FLTVAKWIAH FDEFRKLDQS LQIKLLQAIW HVWSKIHKCA STAFYRKSNP NAKPTQKILR
     NVCMDRMHVH KLDTSWMSDY PTEHVTRFML THHVYDFKIV ESLLKLDPTD VELTFMFAQL
     CFEYAGKRFQ GEILKITDHF QQVLSNDLHH YYITDQRRER YFQRLTDLMK VNNLIQRSIW
     ETRPHRELGR VFEISKLEFS HPEMFDDSGF C