ID   NH121_CAEEL             Reviewed;         461 AA.
AC   Q9TZ99;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Nuclear hormone receptor family member nhr-121;
GN   Name=nhr-121; ORFNames=E02H9.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AY305847; AAR11991.1; -; mRNA.
DR   EMBL; FO081030; CCD68638.1; -; Genomic_DNA.
DR   PIR; T33599; T33599.
DR   RefSeq; NP_497559.2; NM_065158.5.
DR   AlphaFoldDB; Q9TZ99; -.
DR   SMR; Q9TZ99; -.
DR   BioGRID; 48806; 1.
DR   IntAct; Q9TZ99; 2.
DR   STRING; 6239.E02H9.8b.1; -.
DR   PaxDb; Q9TZ99; -.
DR   EnsemblMetazoa; E02H9.8a.1; E02H9.8a.1; WBGene00003711.
DR   GeneID; 184003; -.
DR   KEGG; cel:CELE_E02H9.8; -.
DR   UCSC; E02H9.8b.1; c. elegans.
DR   CTD; 184003; -.
DR   WormBase; E02H9.8a; CE30644; WBGene00003711; nhr-121.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_17_1_1; -.
DR   InParanoid; Q9TZ99; -.
DR   PRO; PR:Q9TZ99; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00003711; Expressed in larva and 2 other tissues.
DR   ExpressionAtlas; Q9TZ99; differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:1990239; F:steroid hormone binding; IDA:WormBase.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..461
FT                   /note="Nuclear hormone receptor family member nhr-121"
FT                   /id="PRO_0000223590"
FT   DOMAIN          185..455
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        19..94
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         22..42
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         58..77
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   461 AA;  52952 MW;  FC5059F1BBFF2B44 CRC64;
     MYYGHEPHDW GTSSSTSDMK ECTICEAPSN GYHFNAASCS ACAAFFRRTV TLNRNFVCTH
     QNTCRVNYAM RVICRACRYH KCINMGMERS AVQPRRDCNA GRRKIMYNST NSLKTQEHTF
     APPTPTVPQT TTVIVTKDER IYEDSSPEIH YAQSYSSSIS EEISSLSPKI SVSMCSGTDI
     TLNFEAEQVL EDLLREERLF NERRKLLYCS NSCISELLTN ENANEIPYSQ SNLQPLTFAG
     IQKHIRPQIL VIYEWLRGWR HFELLNIKDK SVFLRRCVLY HTILDPSYLS YRLGLPEKFV
     MFNGMYVGVQ DGDKTGWEDE KDCITADLKI KLYRPLMDRL INEVCVSMKV INLTFVEFVL
     LKALVCFKSS TTCEVSVPLK KFMNTYMDTI LRALNVHYQT LGMTKEDIAQ RIGNVILMMS
     SIFAVGMECL ESHQKIQFFD LWQLDDLLIK LIQRGGGGAN Y