ID   NH124_CAEEL             Reviewed;         376 AA.
AC   O16391;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 3.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Nuclear hormone receptor family member nhr-124;
GN   Name=nhr-124; ORFNames=C17E7.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY305837; AAR11982.1; -; mRNA.
DR   EMBL; FO080584; CCD64873.1; -; Genomic_DNA.
DR   PIR; T31823; T31823.
DR   RefSeq; NP_504070.2; NM_071669.5.
DR   AlphaFoldDB; O16391; -.
DR   SMR; O16391; -.
DR   EnsemblMetazoa; C17E7.8a.1; C17E7.8a.1; WBGene00003714.
DR   GeneID; 182733; -.
DR   UCSC; C17E7.8b; c. elegans.
DR   CTD; 182733; -.
DR   WormBase; C17E7.8a; CE30728; WBGene00003714; nhr-124.
DR   GeneTree; ENSGT00970000196609; -.
DR   InParanoid; O16391; -.
DR   OrthoDB; 1158645at2759; -.
DR   PhylomeDB; O16391; -.
DR   PRO; PR:O16391; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003714; Expressed in embryo and 2 other tissues.
DR   ExpressionAtlas; O16391; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..376
FT                   /note="Nuclear hormone receptor family member nhr-124"
FT                   /id="PRO_0000223591"
FT   DOMAIN          125..371
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        11..89
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         14..34
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         50..72
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   376 AA;  42844 MW;  96710A7274853F2B CRC64;
     MSGTTISSDR PNICAICHQK AFGYNYEVVS CNACKMFFRR AHAEKIDDFC KKGGKCFDGD
     DLLTSRPKCR SCRYKKCVNL GMRYHNSSES QTQSDEEPSP KQSVVAVVPQ HIITQAHIDS
     TFFQHLHALN ETRYNAYCVI NICEDPSFCD LVAQGSKLSV YLRPQEIEWE NTERKLKPWG
     SLGVLLAVEV CKGLSFYNDL LLSDRVLLLK NVAFKSHHLS VAYDSFIQKK GRVLAPTGTE
     MFPDVLFEIP KCREIIMDLL TSPMKPLMEL QITESEYLLL NMIVICNPAI QGMSPSGQDL
     LSRHQQVYAR ILLQMCMVSN PRTGPGRYAA ILAINQRLDR QSVITNRVVQ CLREYWAPNF
     FFSKILTEAC RSDVYY