NH125_CAEEL
ID NH125_CAEEL Reviewed; 399 AA.
AC O17082;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 3.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=Nuclear hormone receptor family member nhr-125;
GN Name=nhr-125; ORFNames=R02D1.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; FO081013; CCD68492.1; -; Genomic_DNA.
DR PIR; B89024; B89024.
DR PIR; T37257; T37257.
DR RefSeq; NP_504194.2; NM_071793.5.
DR AlphaFoldDB; O17082; -.
DR STRING; 6239.R02D1.1; -.
DR PaxDb; O17082; -.
DR PRIDE; O17082; -.
DR EnsemblMetazoa; R02D1.1a.1; R02D1.1a.1; WBGene00003715.
DR GeneID; 187520; -.
DR KEGG; cel:CELE_R02D1.1; -.
DR UCSC; R02D1.1; c. elegans.
DR CTD; 187520; -.
DR WormBase; R02D1.1a; CE30823; WBGene00003715; nhr-125.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000195869; -.
DR HOGENOM; CLU_007368_7_1_1; -.
DR InParanoid; O17082; -.
DR OrthoDB; 1136195at2759; -.
DR PhylomeDB; O17082; -.
DR PRO; PR:O17082; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003715; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; O17082; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..399
FT /note="Nuclear hormone receptor family member nhr-125"
FT /id="PRO_0000223592"
FT DOMAIN 149..392
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 10..80
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 13..33
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 50..63
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 399 AA; 46533 MW; 085AFBD6214D6823 CRC64;
MDLVSTSTSP FSCRICNQKA HGNHFGVLTC RACASFFRRA AFSKWSQLKC QKGGCSRNFC
KRCRLKKCRE MGMDTTKFQY NRDSFRATGQ FQLPPPRSLA SFVGRPELFL FCDTEAPNAK
MLIDVRYLLE EAGRIINQGY ETPASGKNQL ENLTEGFKYI KVDMNNISSS KYASKDAIIS
MWEYYFFTVT RWLMYFEGFQ KLNSHTQITL IQSVWNVWSR LHKYVATVDY HKANPDTLPT
NVVIHNTLVD IENVEFDSTW LSDYPVEHVR RYLSVQHCRE FDILGTLRKL NPSELEITYL
FAQICFEHAG KRNQGDIMKV TEQFLDSLAN DLHDYYVNEM NNSRYFLRLT QLLKINQAIQ
FSDISPQKQI RNNIIKKEAE KLEKLQKSQF SIKRLSISN
