NH127_CAEEL
ID NH127_CAEEL Reviewed; 355 AA.
AC O18087;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Nuclear hormone receptor family member nhr-127;
GN Name=nhr-127; ORFNames=T13F3.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND INDUCTION.
RX PubMed=29748542; DOI=10.1038/s41598-018-25333-8;
RA Park M.R., Ryu S., Maburutse B.E., Oh N.S., Kim S.H., Oh S., Jeong S.Y.,
RA Jeong D.Y., Oh S., Kim Y.;
RT "Probiotic Lactobacillus fermentum strain JDFM216 stimulates the longevity
RT and immune response of Caenorhabditis elegans through a nuclear hormone
RT receptor.";
RL Sci. Rep. 8:7441-7441(2018).
CC -!- FUNCTION: Orphan nuclear receptor (Probable). May play a role in
CC modulation of lifespan and immunity (PubMed:29748542).
CC {ECO:0000269|PubMed:29748542, ECO:0000305|PubMed:29748542}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- INDUCTION: Transcription up-regulated in response to intestinal
CC colonization by probiotic Lactobacillus fermentum strain JDFM216.
CC {ECO:0000269|PubMed:29748542}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; Z93389; CAB07671.2; -; Genomic_DNA.
DR PIR; T24891; T24891.
DR RefSeq; NP_507104.2; NM_074703.2.
DR AlphaFoldDB; O18087; -.
DR SMR; O18087; -.
DR IntAct; O18087; 1.
DR STRING; 6239.T13F3.3; -.
DR PaxDb; O18087; -.
DR PRIDE; O18087; -.
DR EnsemblMetazoa; T13F3.3.1; T13F3.3.1; WBGene00003717.
DR EnsemblMetazoa; T13F3.3.2; T13F3.3.2; WBGene00003717.
DR GeneID; 188480; -.
DR UCSC; T13F3.3; c. elegans.
DR CTD; 188480; -.
DR WormBase; T13F3.3; CE35617; WBGene00003717; nhr-127.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000195937; -.
DR HOGENOM; CLU_007368_7_0_1; -.
DR InParanoid; O18087; -.
DR OMA; NQERECI; -.
DR OrthoDB; 1136195at2759; -.
DR PhylomeDB; O18087; -.
DR PRO; PR:O18087; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003717; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..355
FT /note="Nuclear hormone receptor family member nhr-127"
FT /id="PRO_0000223702"
FT DOMAIN 126..355
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 10..86
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 13..33
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 49..69
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 355 AA; 41475 MW; E985FFF8130E550D CRC64;
MKITFSPELS IPCEVCKNQS NGYHFEVLSC GACASFFRRS VVSKIKYQCK DGKKRCQIRY
LDRHFCRYCR FSKCVKAGMK AEKIQKNRDL DSSPTPTDQN NCIPSDVLHD DGILIKDIRG
LFKQFNPHNA SEGCSKLEKL TEGLQFIRRN QERECIKIID EMDSESLKDV QFKVIGSCAT
WLLFSSFFQK LEENEKVVIL ERLWHGWTVL EFLSRSLEIF GNKVIDEKIV FISDNTAIRL
ITAFENSLKT ASPKKSESIK KKLELSFSVI FDELALHFIN WKPTEIEISY MQWQIVWSVA
EQLLSGNSLE KGEHFTEQLS KDLHEYYVRE LKLENYAFRI EKMMDIVQIV QNNFY
