NH130_CAEEL
ID NH130_CAEEL Reviewed; 440 AA.
AC O16963;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1999, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Nuclear hormone receptor family member nhr-130;
GN Name=nhr-130; ORFNames=T01G6.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; FO081653; CCD73123.1; -; Genomic_DNA.
DR PIR; T32190; T32190.
DR RefSeq; NP_503216.1; NM_070815.4.
DR AlphaFoldDB; O16963; -.
DR STRING; 6239.T01G6.8; -.
DR EPD; O16963; -.
DR PaxDb; O16963; -.
DR PeptideAtlas; O16963; -.
DR PRIDE; O16963; -.
DR EnsemblMetazoa; T01G6.8.1; T01G6.8.1; WBGene00003720.
DR GeneID; 187965; -.
DR KEGG; cel:CELE_T01G6.8; -.
DR UCSC; T01G6.8; c. elegans.
DR CTD; 187965; -.
DR WormBase; T01G6.8; CE18167; WBGene00003720; nhr-130.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000164378; -.
DR HOGENOM; CLU_007368_7_1_1; -.
DR InParanoid; O16963; -.
DR OMA; GRLNQMM; -.
DR OrthoDB; 1677905at2759; -.
DR PhylomeDB; O16963; -.
DR PRO; PR:O16963; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003720; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..440
FT /note="Nuclear hormone receptor family member nhr-130"
FT /id="PRO_0000223593"
FT DOMAIN 184..439
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 34..110
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 37..57
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 74..93
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 440 AA; 51384 MW; 738AE8A852232476 CRC64;
MQIATSSTSP SIFYTPSISP MEEDMNCQEL VVNLYTCQVC ALPAHGNHFG AISCRACAAF
FRRACTGTKT TYKCKKQNNC DIWENGRYKC KKCRLDRCNE VGMDPGRFQF DRDLISATEK
YPNSKNFRRT FGMSRLPETI EHFLGRPHFI IFLERHIYSH SEKNFVDLQH LIAKASKLLE
LGSEKPLIAR NNLEKLALGL NLVRDQPAGS HDVQLVTKLG KDEALTFWET DFLTVAKWLT
YFDDFQLLPH NQQILLLKSV WHVWNRLEKL ALTATSRRQN VCEQKQLMLT YNSVCNPKTI
ELDYSWFTKY PKEQLCFFFD EMEDYMLTSA LDPLTSLEPT DIELTYMLCQ LCFHYAGKRY
GGEILEVTEK FQENLADNLH DYYVNELNMP RYCGRLNQML KINNLIQQDI WEKRAKHELA
KVFDIFCIEF SHPEMFEDTG
