ID   NH133_CAEEL             Reviewed;         406 AA.
AC   O16354;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Nuclear hormone receptor family member nhr-133;
GN   Name=nhr-133 {ECO:0000312|WormBase:F44C8.8a};
GN   ORFNames=F44C8.8 {ECO:0000312|WormBase:F44C8.8a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; FO081357; CCD71010.1; -; Genomic_DNA.
DR   PIR; T31786; T31786.
DR   RefSeq; NP_503602.1; NM_071201.5.
DR   AlphaFoldDB; O16354; -.
DR   SMR; O16354; -.
DR   BioGRID; 50488; 1.
DR   DIP; DIP-26488N; -.
DR   IntAct; O16354; 1.
DR   STRING; 6239.F44C8.8; -.
DR   EPD; O16354; -.
DR   PaxDb; O16354; -.
DR   PRIDE; O16354; -.
DR   EnsemblMetazoa; F44C8.8a.1; F44C8.8a.1; WBGene00003723.
DR   GeneID; 185729; -.
DR   KEGG; cel:CELE_F44C8.8; -.
DR   UCSC; F44C8.8; c. elegans.
DR   CTD; 185729; -.
DR   WormBase; F44C8.8a; CE10392; WBGene00003723; nhr-133.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000196079; -.
DR   HOGENOM; CLU_007368_7_1_1; -.
DR   InParanoid; O16354; -.
DR   OMA; PCEICEQ; -.
DR   OrthoDB; 1136195at2759; -.
DR   PhylomeDB; O16354; -.
DR   PRO; PR:O16354; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003723; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..406
FT                   /note="Nuclear hormone receptor family member nhr-133"
FT                   /id="PRO_0000223594"
FT   DOMAIN          150..406
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        8..83
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         11..31
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         47..66
FT                   /note="NR C4-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   406 AA;  46768 MW;  A07D842710AD468F CRC64;
     MPPALYLSGP CEICEQPAHG NHFGVLSCRA CAAFFRRAAL QNAKYQDRVC RKGNCIGNDL
     YRCKICRLKK CCEVGMNSSK FQNDRDLISS SLRPTNYTKT SAPQSLANFL GRPEFILCCE
     PDKASSTKRL VDVTSLVDKA WAIFQEDAAY SWSPNHYPNS LEKLTFEMEE IKLKESSKKL
     EIATTIGRNE ALLFLEQSFL GAAQWFARLP EFSMLDPQIK IDILKTSWMI WARLDKLAAT
     ADFHRQKLLG NDVYMWTDNT CMNPGNVKID IKWSSNYSVE QLRGFLVPDI EKYWRHALSD
     LVELDPTNVE LNFMLIQLCL NSAGQKYQGH VLEATEKILQ IQSDNMHEYY TKKLKLVNYS
     GRLARLMKIN RAIEADVRDR KEKNHIAKVF DLFFVEYSHP EMFEFS