NH134_CAEEL
ID NH134_CAEEL Reviewed; 407 AA.
AC O16361;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Nuclear hormone receptor family member nhr-134;
GN Name=nhr-134; ORFNames=F44C8.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; FO081357; CCD71002.1; -; Genomic_DNA.
DR RefSeq; NP_503610.1; NM_071209.5.
DR AlphaFoldDB; O16361; -.
DR SMR; O16361; -.
DR STRING; 6239.F44C8.2.2; -.
DR PaxDb; O16361; -.
DR PeptideAtlas; O16361; -.
DR EnsemblMetazoa; F44C8.2.1; F44C8.2.1; WBGene00003724.
DR GeneID; 185728; -.
DR KEGG; cel:CELE_F44C8.2; -.
DR UCSC; F44C8.2.1; c. elegans.
DR CTD; 185728; -.
DR WormBase; F44C8.2; CE17823; WBGene00003724; nhr-134.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000195928; -.
DR HOGENOM; CLU_007368_7_1_1; -.
DR InParanoid; O16361; -.
DR OMA; WICWTRL; -.
DR OrthoDB; 1114495at2759; -.
DR PhylomeDB; O16361; -.
DR PRO; PR:O16361; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003724; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..407
FT /note="Nuclear hormone receptor family member nhr-134"
FT /id="PRO_0000223595"
FT DOMAIN 157..407
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT ZN_FING 11..31
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 47..66
FT /note="NR C4-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 407 AA; 47144 MW; 5AD99CA6BB2B10FF CRC64;
MPAPLFLSGP CEICGQKTSG RHFGVMSCRS CAAFFRRAAT CSRIFGRCPN GNCKLLENGK
FKCKKCRMKR CLEVGMDETK FQCNRDLISS SNKFQKRVSL IEPPPQSLST FLGRPTLLLC
CEPTRASHIK TLINVTYMVD VARDILKRDV STKIPYQFHN SLERLALSLE EIRSREPDEK
IKMLRKIGQE ESLLIWEQAF LRAVEWFSNF SEFNALDELS KMTILKSAWI SWTRLEKLAE
TADHQRKKIF GDSVMMCGND ACLDLANYEV DLTWCTNYTT EQLLFYLSPE IEQNHFLSLQ
ELVELNPTST ELSYMLLQIT LHLAGKKAQG QLLEITEMLL EAQGNHLHEY YVKKLKMPNY
VMRLAKLMKI NRRIESDMRD RVEKNHIARI FNILKVEFSE PDMFEST
