ID   NH136_CAEEL             Reviewed;         435 AA.
AC   O01930;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Nuclear hormone receptor family member nhr-136;
GN   Name=nhr-136; ORFNames=C13C4.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; Z92825; CAB07314.2; -; Genomic_DNA.
DR   PIR; T19235; T19235.
DR   RefSeq; NP_506039.2; NM_073638.3.
DR   AlphaFoldDB; O01930; -.
DR   SMR; O01930; -.
DR   STRING; 6239.C13C4.3; -.
DR   PaxDb; O01930; -.
DR   EnsemblMetazoa; C13C4.3a.1; C13C4.3a.1; WBGene00003726.
DR   GeneID; 182566; -.
DR   KEGG; cel:CELE_C13C4.3; -.
DR   UCSC; C13C4.3; c. elegans.
DR   CTD; 182566; -.
DR   WormBase; C13C4.3a; CE39470; WBGene00003726; nhr-136.
DR   eggNOG; ENOG502TGMR; Eukaryota.
DR   GeneTree; ENSGT00970000195934; -.
DR   HOGENOM; CLU_007368_3_1_1; -.
DR   InParanoid; O01930; -.
DR   OMA; CLLNYGS; -.
DR   OrthoDB; 792099at2759; -.
DR   PhylomeDB; O01930; -.
DR   PRO; PR:O01930; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003726; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; O01930; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0042594; P:response to starvation; IEP:WormBase.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..435
FT                   /note="Nuclear hormone receptor family member nhr-136"
FT                   /id="PRO_0000053804"
FT   DOMAIN          194..430
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        50..129
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         53..73
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         89..112
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   435 AA;  49080 MW;  D63CB2980EA33A60 CRC64;
     MLPDFITVPS TSEKCLSPEL LLPNMDENLE DSKPSSLKYQ KAMMSRGTCP SNCKVCRHSA
     TGYHYDVPSC NGCKTFFRRS ILDGRKYTCL KMRKCLSGTE PVDLSRRMCR ACRFEKCVEA
     GMNPSAIQAD MKTTDGELLR KEIMIKQKTA VDFLNTPQVI MSFEDKVQGI IGKLTVMELK
     IEPLYTGGLP PGNRDIRKLD ELIDAPLILS YDEIPNLKYC PSVDELTGEI KPSGACYIHC
     GYLASIEYSK MFDFAHKIDV ASKATLIKHA TIMCADIMTA FFSYYQRKSD RLIHPNGMFA
     GPPKYRYGEA GTKYQASMQR TLATVLRHEL NRIEYMLLKA IVLCNPAVSS LSISVQQIIG
     KEREEYVRTL LTYCLLNYGS VHGPSRFSAL LAIMSVLESQ QKNAKDFHLL AKATILKDAV
     RYTRISNLYE QIMES