ID   NH154_CAEEL             Reviewed;         469 AA.
AC   O01931; O02284;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 3.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Nuclear hormone receptor family member nhr-154;
GN   Name=nhr-154; ORFNames=C13C4.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; Z92825; CAB07316.2; -; Genomic_DNA.
DR   EMBL; Z75955; CAB07316.2; JOINED; Genomic_DNA.
DR   PIR; T19238; T19238.
DR   RefSeq; NP_506037.2; NM_073636.2.
DR   AlphaFoldDB; O01931; -.
DR   SMR; O01931; -.
DR   PaxDb; O01931; -.
DR   EnsemblMetazoa; C13C4.2.1; C13C4.2.1; WBGene00007547.
DR   GeneID; 182565; -.
DR   KEGG; cel:CELE_C13C4.2; -.
DR   UCSC; C13C4.2; c. elegans.
DR   CTD; 182565; -.
DR   WormBase; C13C4.2; CE40299; WBGene00007547; nhr-154.
DR   eggNOG; ENOG502R0VT; Eukaryota.
DR   GeneTree; ENSGT00970000195934; -.
DR   HOGENOM; CLU_007368_3_1_1; -.
DR   InParanoid; O01931; -.
DR   OMA; MMNAFFS; -.
DR   OrthoDB; 679924at2759; -.
DR   PhylomeDB; O01931; -.
DR   PRO; PR:O01931; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00007547; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0042594; P:response to starvation; IEP:WormBase.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..469
FT                   /note="Nuclear hormone receptor family member nhr-154"
FT                   /id="PRO_0000223598"
FT   DOMAIN          230..459
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        80..159
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         83..103
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         119..142
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   469 AA;  54250 MW;  04918A131A22BBE4 CRC64;
     MTTFEEFESP STSFNFQTFD RYQPDFKMID YSHQQATHEY HLPDQEVFQN QNEFSASPPD
     ISSPFADEKI YKSLPRNKCP SKCLVCRNPA IGYHYDVPSC NGCKTFFRRT IITGRKFTCA
     KQKKCMDGTE PVDMSKRLCR ACRFAKCVEV GMNPMAIQAE VKTDEGKVLR SEVLNQRESL
     GVVSSLIVTE EDLLSRMIEK LTFVESKVEP LHRSGMPPGY RDIRKLEEIL DSKPVLVVTD
     IPNLKFCPSP CANEKRPRRH FTNYVHTSYL ASLESSKMFE FSSQLDLESR ILLMKHATLI
     CSNMMNAFFS INEMKSDILR HPDGSMSGHM RKFDRENDVM TDHVKLIQKT LITFLNHKVD
     KIEYLLFKAI MLCNPAVPGL DSWNQEIIEK ERNQYVKALL NYCLLQHGKL QGPTRFATIL
     AMAPIIENQS KNQKDFHVYI KAKHFQKHKK MGTTFRKCIS CMFDQIMET