NH169_CAEEL
ID NH169_CAEEL Reviewed; 356 AA.
AC O17706;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Nuclear hormone receptor family member nhr-169;
GN Name=nhr-169; ORFNames=C54C8.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; Z83102; CAB05462.2; -; Genomic_DNA.
DR PIR; T20200; T20200.
DR RefSeq; NP_493156.2; NM_060755.2.
DR AlphaFoldDB; O17706; -.
DR SMR; O17706; -.
DR BioGRID; 48578; 1.
DR IntAct; O17706; 1.
DR STRING; 6239.C54C8.1; -.
DR PaxDb; O17706; -.
DR EnsemblMetazoa; C54C8.1.1; C54C8.1.1; WBGene00008289.
DR GeneID; 183768; -.
DR KEGG; cel:CELE_C54C8.1; -.
DR UCSC; C54C8.1; c. elegans.
DR CTD; 183768; -.
DR WormBase; C54C8.1; CE36114; WBGene00008289; nhr-169.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000195849; -.
DR HOGENOM; CLU_066719_0_0_1; -.
DR InParanoid; O17706; -.
DR OrthoDB; 1214776at2759; -.
DR PhylomeDB; O17706; -.
DR PRO; PR:O17706; -.
DR Proteomes; UP000001940; Chromosome I.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..356
FT /note="Nuclear hormone receptor family member nhr-169"
FT /id="PRO_0000223601"
FT DOMAIN 144..356
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 16..90
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 19..40
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 56..72
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 356 AA; 41272 MW; D09769DBB4B0B2D9 CRC64;
MKLSTSLEMP FRESTDPICS VCNFSSLIAP HFGGLVCSAC ASFFRRTVAL NIHYLCKKDN
QCKGMRKNCR ACRFESCVKI AGMKRSLVKE RKNLNNIPLY ILNRRNETGN QGVVRAFVSS
NQNRLENRLS LSPLTELPIN DEMDVSKILK TTPSSLLKYY VEQVSHGKQF YMNTLNIRTK
EELFEIVSYQ SKVAAETCRT CPGVDLLDNR DILILRKYFQ FSNIWIESTW KYWFSNDFSN
DTEKFDIKLM EFIGQVKSTL LISLSRLKFN IFEFTAFKAI CIWKLVYHET SRAMKIVAQE
HYEGVTKALI SYYQTYTLLD SMEIAIRVGE ITLLVSSVFQ MYHDMAKLYL HMGLPF
