NH174_CAEEL
ID NH174_CAEEL Reviewed; 319 AA.
AC O17748;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Nuclear hormone receptor family member nhr-174;
GN Name=nhr-174; ORFNames=E03H4.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; BX284601; CAB04030.3; -; Genomic_DNA.
DR PIR; T20444; T20444.
DR RefSeq; NP_493149.2; NM_060748.3.
DR AlphaFoldDB; O17748; -.
DR SMR; O17748; -.
DR STRING; 6239.E03H4.6; -.
DR PaxDb; O17748; -.
DR EnsemblMetazoa; E03H4.6.1; E03H4.6.1; WBGene00008474.
DR GeneID; 184021; -.
DR KEGG; cel:CELE_E03H4.6; -.
DR UCSC; E03H4.6; c. elegans.
DR CTD; 184021; -.
DR WormBase; E03H4.6; CE42474; WBGene00008474; nhr-174.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000195849; -.
DR HOGENOM; CLU_066719_0_0_1; -.
DR InParanoid; O17748; -.
DR OMA; VWIESAW; -.
DR OrthoDB; 1214776at2759; -.
DR PhylomeDB; O17748; -.
DR PRO; PR:O17748; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00008474; Expressed in pharyngeal muscle cell (C elegans).
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..319
FT /note="Nuclear hormone receptor family member nhr-174"
FT /id="PRO_0000223602"
FT DOMAIN 130..319
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 7..81
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 10..31
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 47..63
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 319 AA; 36920 MW; 66AB1FCAF5ADCD47 CRC64;
MTIILTDPVC PVCEFPSNVE LHFGGLVCGA CAAFFRRTVS LNIRYLCEKK NQCKGKRKNC
RACRFDYCVK IAGMKRNLVR QRKNSTNTPM YILNRRKDSG NEEVVRGFVT STQSKWAQHS
RKSSMSPNKE AEKDVSKILK ISHGRLLKYY IYQITQGKWV NMNTLNIKSV EEFLEITSIH
NKLAAEICKT CPGVDLLDNE DILTIRKYFQ FSNVWIESAW NYLMSADKHV QIDDSELDLT
LLKFINQVKS TLLVSLSQLK FNTIEFAAFK SICIWKLVYH GTSRAMKIIA QEHYEGVAKA
LNDYYQTYTS MKKSRYLQF
