NH199_CAEEL
ID NH199_CAEEL Reviewed; 405 AA.
AC O17934;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Nuclear hormone receptor family member nhr-199;
GN Name=nhr-199; ORFNames=K06B4.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; Z83233; CAB05766.1; -; Genomic_DNA.
DR PIR; T23370; T23370.
DR RefSeq; NP_506905.1; NM_074504.1.
DR AlphaFoldDB; O17934; -.
DR SMR; O17934; -.
DR BioGRID; 51764; 4.
DR STRING; 6239.K06B4.10; -.
DR PaxDb; O17934; -.
DR PRIDE; O17934; -.
DR EnsemblMetazoa; K06B4.10.1; K06B4.10.1; WBGene00010604.
DR GeneID; 187058; -.
DR KEGG; cel:CELE_K06B4.10; -.
DR UCSC; K06B4.10; c. elegans.
DR CTD; 187058; -.
DR WormBase; K06B4.10; CE11800; WBGene00010604; nhr-199.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000196534; -.
DR HOGENOM; CLU_007368_1_1_1; -.
DR InParanoid; O17934; -.
DR OrthoDB; 800382at2759; -.
DR PhylomeDB; O17934; -.
DR PRO; PR:O17934; -.
DR Proteomes; UP000001940; Chromosome V.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 2.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..405
FT /note="Nuclear hormone receptor family member nhr-199"
FT /id="PRO_0000223604"
FT DOMAIN 126..376
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 20..111
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 23..44
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 60..94
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 405 AA; 46059 MW; B2588728877F09F9 CRC64;
MFTLARVLNN IGSASSNEPI PYCLICSEVA DGNHFGVAAA CRACAAFFRR TVQHNKIHEC
GRNGQCFFLS CKFLLVGFQI SPLSSDARSM CKACRYGKCL EMGMQRSSVQ QRREQLGKRL
NISDDRGKPV LNKLRRAYEM LILNRKHVHN RRENQAPRAI GFNELPIVFQ NESTSIYQFL
WEAFPEYSML LPDTKLAFFK NFFLSFCLFE SSFNGCSAKQ KNVMLIPSGD YIDLAHSESF
FTNDHQTFTE RDNIEILAQR LKLIQSSITV PLSAENVDIY EFLALAGIIL LESDSESEAD
FQEEAVKIKS NIIKDLLFHY QCINIYDDAA MRLGAVLSIL PSIQVCCSRS NNFLIINSKD
VSESQSPFSR IHGNQKYAQF VRSSQESLRH VLANFIKFIC KFVSI
