ID   NH209_CAEEL             Reviewed;         418 AA.
AC   Q21806;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 2.
DT   03-AUG-2022, entry version 171.
DE   RecName: Full=Nuclear hormone receptor family member nhr-209 {ECO:0000305};
GN   Name=nhr-209 {ECO:0000312|WormBase:R07B7.16};
GN   ORFNames=R07B7.16 {ECO:0000312|WormBase:R07B7.16};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|EMBL:CAB00125.2, ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND INDUCTION.
RX   PubMed=29748542; DOI=10.1038/s41598-018-25333-8;
RA   Park M.R., Ryu S., Maburutse B.E., Oh N.S., Kim S.H., Oh S., Jeong S.Y.,
RA   Jeong D.Y., Oh S., Kim Y.;
RT   "Probiotic Lactobacillus fermentum strain JDFM216 stimulates the longevity
RT   and immune response of Caenorhabditis elegans through a nuclear hormone
RT   receptor.";
RL   Sci. Rep. 8:7441-7441(2018).
CC   -!- FUNCTION: Transcriptional regulator (By similarity). Plays a role in
CC       modulation of lifespan and immunity (PubMed:29748542).
CC       {ECO:0000250|UniProtKB:P41235, ECO:0000269|PubMed:29748542}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU004334}.
CC   -!- INDUCTION: Transcription up-regulated in response to intestinal
CC       colonization by probiotic Lactobacillus fermentum strain JDFM216.
CC       {ECO:0000269|PubMed:29748542}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000255|RuleBase:RU004334, ECO:0000305}.
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DR   EMBL; BX284605; CAB00125.2; -; Genomic_DNA.
DR   RefSeq; NP_506036.2; NM_073635.2.
DR   AlphaFoldDB; Q21806; -.
DR   SMR; Q21806; -.
DR   STRING; 6239.R07B7.16; -.
DR   PaxDb; Q21806; -.
DR   EnsemblMetazoa; R07B7.16.1; R07B7.16.1; WBGene00011100.
DR   GeneID; 187663; -.
DR   KEGG; cel:CELE_R07B7.16; -.
DR   UCSC; R07B7.16; c. elegans.
DR   CTD; 187663; -.
DR   WormBase; R07B7.16; CE42934; WBGene00011100; nhr-209.
DR   eggNOG; ENOG502TM8U; Eukaryota.
DR   GeneTree; ENSGT00970000195934; -.
DR   HOGENOM; CLU_007368_3_1_1; -.
DR   InParanoid; Q21806; -.
DR   OMA; YMHSALL; -.
DR   OrthoDB; 959413at2759; -.
DR   PhylomeDB; Q21806; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00011100; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..418
FT                   /note="Nuclear hormone receptor family member nhr-209"
FT                   /id="PRO_0000455560"
FT   DOMAIN          174..414
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        43..121
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         46..66
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         82..104
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          403..414
FT                   /note="AF-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
SQ   SEQUENCE   418 AA;  47478 MW;  81A90F9E6509E225 CRC64;
     MSFLVLPLHH SNETQSSSSA LEKSIPEKDL KKPYQLLSKN QFPEKCAVCK NAAIGYHYNV
     PSCNGCKTFF RRTILNGKRF ICMNHKNCLD EIESDESQRL CKGCRFARCI EVGMDSTAIR
     ASVKTVEGKY LLEEVLRKQK NRKIQMQQKD NFLSLIIKQL SHLEDQIEKL HFSTIPDGFE
     DMRSLSEILL YNPVFDSSRI PNLTPVSNKA PKLICMTYMH SALLAAVEAS KTFEFFSKIS
     HEARMILIRH VSLIGSNMMS ASFSMHHRKS DELLLPDGTV FGSIGGCLAS EVLGEIKYKN
     QLQQILHAFL RINVDRVEYM ILKAILMRNP SVPGLTLDDQ LIIENERNQY AKALLEYTIL
     HHGVLSGPAR FGSLIAINPI IETQSKKQKD VYVFMKTLSA QRECSHPPKS LFDEVMDS