NH217_CAEEL
ID NH217_CAEEL Reviewed; 383 AA.
AC O02305;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Nuclear hormone receptor family member nhr-217;
GN Name=nhr-217; ORFNames=T09E11.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; Z81147; CAB03532.2; -; Genomic_DNA.
DR PIR; T24738; T24738.
DR RefSeq; NP_493122.2; NM_060721.2.
DR AlphaFoldDB; O02305; -.
DR SMR; O02305; -.
DR STRING; 6239.T09E11.2; -.
DR PaxDb; O02305; -.
DR EnsemblMetazoa; T09E11.2.1; T09E11.2.1; WBGene00011651.
DR GeneID; 188330; -.
DR KEGG; cel:CELE_T09E11.2; -.
DR UCSC; T09E11.2; c. elegans.
DR CTD; 188330; -.
DR WormBase; T09E11.2; CE42165; WBGene00011651; nhr-217.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000195849; -.
DR HOGENOM; CLU_066719_0_0_1; -.
DR InParanoid; O02305; -.
DR OrthoDB; 1214776at2759; -.
DR PhylomeDB; O02305; -.
DR PRO; PR:O02305; -.
DR Proteomes; UP000001940; Chromosome I.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00105; zf-C4; 1.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..383
FT /note="Nuclear hormone receptor family member nhr-217"
FT /id="PRO_0000223606"
FT DOMAIN 172..383
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 53..127
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 56..77
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 93..109
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 383 AA; 43705 MW; 66D9C6DB0DA304AC CRC64;
MCRSVSNMLD RISGLSKDAS PNSTTTIQEI ITLEKCLTSK VSALFLICKM LKIPACPVCD
VPCRIEPHFG GIACAACAAF FRRTVSLNIG YMCKREKLCR KARKSCRACR FERCVKSAGL
QRDYVRQLLT PRNTPLYILN RQDNTGGEIV RAFASPTMPK PEPTPQLGFS DILKVSNSSL
FKFYLNQVEK AVKLRQKNTL TIKTNAELLK IVATQQELAL EACRTCPGMD LLDKEDRKVV
QKYFVFSNVW IESTWLYSLA KEHLETENNL NFDINLKKFI EQVKSTLLFS FSQFKLNIFE
LAAFKAICIW KLIYHETSRA MKIIAQEHYD GVASALRNYY ETHTSMDHSE IAIRIGEITL
LVVSIFQLYH DMAKLYVQIG IPF
