NH218_CAEEL
ID NH218_CAEEL Reviewed; 391 AA.
AC O18086;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Nuclear hormone receptor family member nhr-218;
GN Name=nhr-218; ORFNames=T13F3.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; Z93389; CAB07670.2; -; Genomic_DNA.
DR PIR; T24890; T24890.
DR RefSeq; NP_507103.2; NM_074702.3.
DR AlphaFoldDB; O18086; -.
DR SMR; O18086; -.
DR STRING; 6239.T13F3.2a; -.
DR PaxDb; O18086; -.
DR EnsemblMetazoa; T13F3.2a.1; T13F3.2a.1; WBGene00011750.
DR GeneID; 188479; -.
DR KEGG; cel:CELE_T13F3.2; -.
DR UCSC; T13F3.2; c. elegans.
DR CTD; 188479; -.
DR WormBase; T13F3.2a; CE41022; WBGene00011750; nhr-218.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000196028; -.
DR HOGENOM; CLU_007368_7_0_1; -.
DR InParanoid; O18086; -.
DR OMA; ILKTTWH; -.
DR OrthoDB; 1218602at2759; -.
DR PhylomeDB; O18086; -.
DR PRO; PR:O18086; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011750; Expressed in embryo.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..391
FT /note="Nuclear hormone receptor family member nhr-218"
FT /id="PRO_0000223607"
FT DOMAIN 146..391
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 17..93
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 20..40
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 56..76
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 391 AA; 46162 MW; 0EA85F7362120546 CRC64;
MVASSFQHHL EPMLTQPIPC QICTYQSHGV NFNVMTCRAC AAFFRRSLVC GMRYHCKTRK
NDCRIDSTER HFCRLCRFQK CLQMGMKAEK IQQNRDPISS TFPGTSTEPE LSEIVDPENE
KSYIFHGTLY GFKSLLAEVR YIFSISRNYS DSPLTDLENG FKLITRHQKR RYIDIEDRIN
FQNLTDFRLG HIKNCATWLT HSSFFQSLTE TENLLILKST WHVWSWLELL SVSVEIFGNQ
VCEEKIVFLS EKIAVDIVKV FRYILKPLNK QEKRKVEKEL NPIFHILFDD VARKLQNLKP
SSLEINYMLW QLVWFVAEKV LNEDNLRHGE QYTNQLASDL HNHYKNDLHL EQYAQRVLKM
MAIVKSLQKH LMNIHKIIDY ADNFCNLFAM K
