ID   NH2L1_CAEEL             Reviewed;         128 AA.
AC   Q21568;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=NHP2-like protein 1 homolog;
GN   ORFNames=M28.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Binds to the 5'-stem-loop of U4 snRNA and may play a role in
CC       the late stage of spliceosome assembly. The protein undergoes a
CC       conformational change upon RNA-binding (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000305}.
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DR   EMBL; Z49911; CAA90127.1; -; Genomic_DNA.
DR   PIR; T23808; T23808.
DR   RefSeq; NP_496300.1; NM_063899.5.
DR   AlphaFoldDB; Q21568; -.
DR   SMR; Q21568; -.
DR   BioGRID; 39959; 13.
DR   STRING; 6239.M28.5.2; -.
DR   EPD; Q21568; -.
DR   PaxDb; Q21568; -.
DR   PeptideAtlas; Q21568; -.
DR   EnsemblMetazoa; M28.5.1; M28.5.1; WBGene00010896.
DR   UCSC; M28.5.1; c. elegans.
DR   WormBase; M28.5; CE02283; WBGene00010896; -.
DR   eggNOG; KOG3387; Eukaryota.
DR   GeneTree; ENSGT00550000074840; -.
DR   HOGENOM; CLU_084513_4_1_1; -.
DR   InParanoid; Q21568; -.
DR   OMA; MQSSPQC; -.
DR   OrthoDB; 1497609at2759; -.
DR   PhylomeDB; Q21568; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-CEL-72165; mRNA Splicing - Minor Pathway.
DR   PRO; PR:Q21568; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00010896; Expressed in embryo and 4 other tissues.
DR   GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR   InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00883; NUCLEARHMG.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..128
FT                   /note="NHP2-like protein 1 homolog"
FT                   /id="PRO_0000136781"
SQ   SEQUENCE   128 AA;  14001 MW;  445C4BF3504E45F0 CRC64;
     MADDGVNPKA FPLADTNLSQ KLMDLVQQAM NYKQLKKGAN EATKTLNRGI SEIIVMAADA
     EPLEILLHLP LLCEDKNVPY VFVRSKAALG RACGVTRPVI AASITQNEGS QLKSQIQKIK
     EDVEKLLI