ID   NH2L1_DROME             Reviewed;         127 AA.
AC   Q9U3Z7; Q9VL98;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=NHP2-like protein 1 homolog;
DE   AltName: Full=Protein hoi-polloi;
GN   Name=hoip; ORFNames=CG3949;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Prokopenko S.N., He Y., Lu Y., Bellen H.J.;
RT   "Mutations affecting the development of the peripheral nervous system in
RT   Drosophila: a molecular screen for novel genes.";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- FUNCTION: Binds to the 5'-stem-loop of U4 snRNA and may play a role in
CC       the late stage of spliceosome assembly. The protein undergoes a
CC       conformational change upon RNA-binding (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000305}.
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DR   EMBL; AF208396; AAF20209.1; -; mRNA.
DR   EMBL; AE014134; AAF52798.2; -; Genomic_DNA.
DR   RefSeq; NP_001260293.1; NM_001273364.1.
DR   RefSeq; NP_524714.1; NM_079975.4.
DR   AlphaFoldDB; Q9U3Z7; -.
DR   SMR; Q9U3Z7; -.
DR   BioGRID; 68878; 19.
DR   DIP; DIP-21473N; -.
DR   IntAct; Q9U3Z7; 1.
DR   STRING; 7227.FBpp0079443; -.
DR   PaxDb; Q9U3Z7; -.
DR   PRIDE; Q9U3Z7; -.
DR   DNASU; 44173; -.
DR   EnsemblMetazoa; FBtr0079846; FBpp0079443; FBgn0286786.
DR   EnsemblMetazoa; FBtr0335494; FBpp0307465; FBgn0286786.
DR   GeneID; 44173; -.
DR   KEGG; dme:Dmel_CG3949; -.
DR   UCSC; CG3949-RA; d. melanogaster.
DR   CTD; 44173; -.
DR   FlyBase; FBgn0286786; hoip.
DR   VEuPathDB; VectorBase:FBgn0286786; -.
DR   eggNOG; KOG3387; Eukaryota.
DR   GeneTree; ENSGT00550000074840; -.
DR   HOGENOM; CLU_084513_4_1_1; -.
DR   InParanoid; Q9U3Z7; -.
DR   OMA; MQSSPQC; -.
DR   OrthoDB; 1497609at2759; -.
DR   PhylomeDB; Q9U3Z7; -.
DR   Reactome; R-DME-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DME-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-DME-72165; mRNA Splicing - Minor Pathway.
DR   SignaLink; Q9U3Z7; -.
DR   BioGRID-ORCS; 44173; 1 hit in 1 CRISPR screen.
DR   GenomeRNAi; 44173; -.
DR   PRO; PR:Q9U3Z7; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0286786; Expressed in adult abdomen and 28 other tissues.
DR   ExpressionAtlas; Q9U3Z7; baseline and differential.
DR   Genevisible; Q9U3Z7; DM.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071011; C:precatalytic spliceosome; HDA:FlyBase.
DR   GO; GO:0030532; C:small nuclear ribonucleoprotein complex; ISS:FlyBase.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:FlyBase.
DR   GO; GO:0060415; P:muscle tissue morphogenesis; IMP:FlyBase.
DR   GO; GO:0045727; P:positive regulation of translation; IMP:FlyBase.
DR   GO; GO:0010608; P:post-transcriptional regulation of gene expression; IMP:FlyBase.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR   InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00883; NUCLEARHMG.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..127
FT                   /note="NHP2-like protein 1 homolog"
FT                   /id="PRO_0000136782"
SQ   SEQUENCE   127 AA;  13883 MW;  E3CA6F5389A1F0A4 CRC64;
     MTEEVNPKAF PLADAQLTAK IMNLLQQALN YNQLRKGANE ATKTLNRGLA DIVVLAGDAE
     PIEILLHLPL LCEDKNVPYV FVRSKQALGR ACGVSRPIVA CSVTTNEGSQ LKSQITSIQQ
     EIERLLV