NH2L1_XENLA
ID NH2L1_XENLA Reviewed; 128 AA.
AC Q5XH16;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=NHP2-like protein 1;
DE AltName: Full=High mobility group-like nuclear protein 2 homolog 1;
DE AltName: Full=U4/U6.U5 small nuclear ribonucleoprotein SNU13 {ECO:0000250|UniProtKB:P55769};
DE AltName: Full=U4/U6.U5 tri-snRNP 15.5 kDa protein;
GN Name=snu13 {ECO:0000250|UniProtKB:P55769}; Synonyms=nhp2l1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby
CC contributes to spliceosome assembly. The protein undergoes a
CC conformational change upon RNA-binding. {ECO:0000250|UniProtKB:P55769}.
CC -!- SUBUNIT: Identified in the spliceosome B complex. Component of the
CC U4/U6-U5 tri-snRNP complex. {ECO:0000250|UniProtKB:P55769}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P55769}. Nucleus,
CC nucleolus {ECO:0000250|UniProtKB:P55769}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC084259; AAH84259.1; -; mRNA.
DR RefSeq; NP_001088399.1; NM_001094930.1.
DR AlphaFoldDB; Q5XH16; -.
DR SMR; Q5XH16; -.
DR BioGRID; 105333; 1.
DR MaxQB; Q5XH16; -.
DR DNASU; 495253; -.
DR GeneID; 495253; -.
DR KEGG; xla:495253; -.
DR CTD; 495253; -.
DR Xenbase; XB-GENE-963828; snu13.S.
DR OMA; KPFYVRF; -.
DR OrthoDB; 1497609at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 495253; Expressed in gastrula and 19 other tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR GO; GO:0005690; C:U4atac snRNP; ISS:UniProtKB.
DR GO; GO:0030622; F:U4atac snRNA binding; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:InterPro.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00881; L7ARS6FAMILY.
DR PRINTS; PR00883; NUCLEARHMG.
DR SUPFAM; SSF55315; SSF55315; 1.
DR PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE 2: Evidence at transcript level;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..128
FT /note="NHP2-like protein 1"
FT /id="PRO_0000320040"
FT REGION 36..48
FT /note="Interaction with U4 snRNA and U4atac snRNA"
FT /evidence="ECO:0000250|UniProtKB:P55769"
FT REGION 96..128
FT /note="Important for U4 snRNA-binding"
FT /evidence="ECO:0000250|UniProtKB:P55769"
FT SITE 61
FT /note="Interaction with U4 snRNA and U4atac snRNA"
FT /evidence="ECO:0000250|UniProtKB:P55769"
FT SITE 86
FT /note="Interaction with U4 snRNA and U4atac snRNA"
FT /evidence="ECO:0000250|UniProtKB:P55769"
SQ SEQUENCE 128 AA; 14068 MW; 6E4F69C17B75683D CRC64;
MTEPEVNPKA YPLADAQLTK TLLDLVQQSA NYKQLRKGAN EATKTLNRGI AEFIVMAADA
EPLEIILHLP LLCEDKNVPY VFVRSKQALG RACGVSRPVI ACSVTIKEGS QLKPQIQSVQ
QAIERLLV