ID   NH2L1_XENTR             Reviewed;         128 AA.
AC   Q6P8E9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=NHP2-like protein 1;
DE   AltName: Full=High mobility group-like nuclear protein 2 homolog 1;
DE   AltName: Full=U4/U6.U5 small nuclear ribonucleoprotein SNU13 {ECO:0000250|UniProtKB:P55769};
DE   AltName: Full=U4/U6.U5 tri-snRNP 15.5 kDa protein;
GN   Name=snu13 {ECO:0000250|UniProtKB:P55769}; Synonyms=nhp2l1;
GN   ORFNames=TGas123b15.1, TNeu005n20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula, and Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC       spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby
CC       contributes to spliceosome assembly. The protein undergoes a
CC       conformational change upon RNA-binding. {ECO:0000250|UniProtKB:P55769}.
CC   -!- SUBUNIT: Identified in the spliceosome B complex. Component of the
CC       U4/U6-U5 tri-snRNP complex. {ECO:0000250|UniProtKB:P55769}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P55769}. Nucleus,
CC       nucleolus {ECO:0000250|UniProtKB:P55769}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000305}.
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DR   EMBL; CR760372; CAJ83019.1; -; mRNA.
DR   EMBL; CR761482; CAJ83900.1; -; mRNA.
DR   EMBL; BC061279; AAH61279.1; -; mRNA.
DR   RefSeq; NP_988994.1; NM_203663.1.
DR   AlphaFoldDB; Q6P8E9; -.
DR   SMR; Q6P8E9; -.
DR   STRING; 8364.ENSXETP00000055093; -.
DR   PaxDb; Q6P8E9; -.
DR   DNASU; 394590; -.
DR   Ensembl; ENSXETT00000055093; ENSXETP00000055093; ENSXETG00000026024.
DR   GeneID; 394590; -.
DR   KEGG; xtr:394590; -.
DR   CTD; 4809; -.
DR   eggNOG; KOG3387; Eukaryota.
DR   HOGENOM; CLU_084513_4_1_1; -.
DR   InParanoid; Q6P8E9; -.
DR   OMA; KPFYVRF; -.
DR   OrthoDB; 1497609at2759; -.
DR   PhylomeDB; Q6P8E9; -.
DR   TreeFam; TF300184; -.
DR   Reactome; R-XTR-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-XTR-72165; mRNA Splicing - Minor Pathway.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026024; Expressed in gastrula and 13 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR   GO; GO:0005690; C:U4atac snRNP; ISS:UniProtKB.
DR   GO; GO:0030622; F:U4atac snRNA binding; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR002415; H/ACA_rnp_Nhp2-like.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR   InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00883; NUCLEARHMG.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..128
FT                   /note="NHP2-like protein 1"
FT                   /id="PRO_0000320041"
FT   REGION          36..48
FT                   /note="Interaction with U4 snRNA and U4atac snRNA"
FT                   /evidence="ECO:0000250|UniProtKB:P55769"
FT   REGION          96..128
FT                   /note="Important for U4 snRNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:P55769"
FT   SITE            61
FT                   /note="Interaction with U4 snRNA and U4atac snRNA"
FT                   /evidence="ECO:0000250|UniProtKB:P55769"
FT   SITE            86
FT                   /note="Interaction with U4 snRNA and U4atac snRNA"
FT                   /evidence="ECO:0000250|UniProtKB:P55769"
SQ   SEQUENCE   128 AA;  14066 MW;  23E1C0EA850C97C3 CRC64;
     MTEPEVNPKA YPLADAQLTK TLLDLVQQAA NYKQLRKGAN EATKTLNRGI AEFIVMAADA
     EPLEIILHLP LLCEDKNVPY VFVRSKQALG RACGVSRPVI ACAVTIKEGS QLKPQIQSLQ
     QSIERLLV