NHAA1_MYCVP
ID NHAA1_MYCVP Reviewed; 617 AA.
AC A1T2V5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Na(+)/H(+) antiporter NhaA 1 {ECO:0000255|HAMAP-Rule:MF_01844};
DE AltName: Full=Sodium/proton antiporter NhaA 1 {ECO:0000255|HAMAP-Rule:MF_01844};
GN Name=nhaA1 {ECO:0000255|HAMAP-Rule:MF_01844}; OrderedLocusNames=Mvan_0667;
OS Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=350058;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 /
RC PYR-1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Anderson I.J., Miller C., Richardson P.;
RT "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01844};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the NhaA Na(+)/H(+)
CC (TC 2.A.33) antiporter family. {ECO:0000305}.
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DR EMBL; CP000511; ABM11505.1; -; Genomic_DNA.
DR AlphaFoldDB; A1T2V5; -.
DR SMR; A1T2V5; -.
DR STRING; 350058.Mvan_0667; -.
DR EnsemblBacteria; ABM11505; ABM11505; Mvan_0667.
DR KEGG; mva:Mvan_0667; -.
DR eggNOG; COG1651; Bacteria.
DR eggNOG; COG3004; Bacteria.
DR HOGENOM; CLU_015803_3_0_11; -.
DR OMA; TFFFFIV; -.
DR Proteomes; UP000009159; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 1.20.1530.10; -; 1.
DR HAMAP; MF_01844; NhaA; 1.
DR InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR InterPro; IPR004670; NhaA.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR30341; PTHR30341; 1.
DR Pfam; PF06965; Na_H_antiport_1; 1.
DR Pfam; PF13462; Thioredoxin_4; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR00773; NhaA; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..617
FT /note="Na(+)/H(+) antiporter NhaA 1"
FT /id="PRO_0000334482"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT DOMAIN 434..617
FT /note="Thioredoxin"
FT REGION 1..433
FT /note="Na(+)/H(+) antiporter NhaA"
SQ SEQUENCE 617 AA; 66904 MW; 72F43CB49B45C919 CRC64;
MTVTEQTTAR GFPLLPSRLS RGSQATRTTD NTAAALLLTF TVIAILWANS PWAQSYSTLL
ETHIGFGFGD HHFEMTVKHL VNDALMTFFF FIVGLEVTRE FTIGELTDRS RAAVPVVAAA
AGLIVPAIVF LAFNPSGDNA HAWGVVISTD TAFLVGALAI IKPKFPARVR LFLLTLAVVD
DVGALVAIAV FYSDAIQVGP LVVAVAVLVA LALVRFLPVA RGPAYAVLGV ALWVALYLAG
IHPTLAGVAV ALLIPVFTPE RRPVERAVDQ IRAFRQSPNS QYARAASRSL RESISINERM
QTAVGPAVSF VILPLFALVN AGVLLDGQSL MTALRSPLTW GVVAGLVIGK FVGITGATWL
MRRTGLGVLA PGLTLRRIAG GAALSGIGFT ISLFIVDIAI SDSSRQDQAR IGVLAASVLA
FVFGWAIFRI TDWLSPPEPV GLKLLRPVEP DRDHVRGRYD APLVLVEYGD FECPFCSRAT
GAIDEVRAHF GDDLLYVWRH FPLERAHPRA FDAARASEAA ALQGKFWEMA HELFDHQDDL
EWSDMYRYAV AAGCDIEQFD QDVRVHSSKV LHRVTDDAED AEAMDLNATP TLFVNGIRHK
GPWDAASLIR ALEAGRR
