NHAA1_SALAI
ID NHAA1_SALAI Reviewed; 652 AA.
AC A8LVS8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Na(+)/H(+) antiporter NhaA 1 {ECO:0000255|HAMAP-Rule:MF_01844};
DE AltName: Full=Sodium/proton antiporter NhaA 1 {ECO:0000255|HAMAP-Rule:MF_01844};
GN Name=nhaA1 {ECO:0000255|HAMAP-Rule:MF_01844}; OrderedLocusNames=Sare_1658;
OS Salinispora arenicola (strain CNS-205).
OC Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC Salinispora.
OX NCBI_TaxID=391037;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNS-205;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Foster B., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Jensen P.R., Moore B.S., Penn K., Jenkins C.,
RA Udwary D., Xiang L., Gontang E., Richardson P.;
RT "Complete sequence of Salinispora arenicola CNS-205.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01844};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the NhaA Na(+)/H(+)
CC (TC 2.A.33) antiporter family. {ECO:0000305}.
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DR EMBL; CP000850; ABV97546.1; -; Genomic_DNA.
DR RefSeq; WP_012181852.1; NC_009953.1.
DR AlphaFoldDB; A8LVS8; -.
DR SMR; A8LVS8; -.
DR STRING; 391037.Sare_1658; -.
DR EnsemblBacteria; ABV97546; ABV97546; Sare_1658.
DR GeneID; 5703559; -.
DR KEGG; saq:Sare_1658; -.
DR PATRIC; fig|391037.6.peg.1684; -.
DR eggNOG; COG1651; Bacteria.
DR eggNOG; COG3004; Bacteria.
DR HOGENOM; CLU_015803_3_0_11; -.
DR OMA; WINSGLM; -.
DR OrthoDB; 1805428at2; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 1.20.1530.10; -; 1.
DR HAMAP; MF_01844; NhaA; 1.
DR InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR InterPro; IPR004670; NhaA.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR30341; PTHR30341; 1.
DR Pfam; PF06965; Na_H_antiport_1; 1.
DR Pfam; PF13462; Thioredoxin_4; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR00773; NhaA; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..652
FT /note="Na(+)/H(+) antiporter NhaA 1"
FT /id="PRO_0000334486"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT DOMAIN 428..623
FT /note="Thioredoxin"
FT REGION 1..427
FT /note="Na(+)/H(+) antiporter NhaA"
FT REGION 626..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 70665 MW; 0DCA1CBF3082550B CRC64;
MTGELPRGRR WSARTTWASR LNVPLRAFLH TETGSARVLL AAAVVALAWA NLDESSYESL
WGNTLSVQLG GWQLSHDLRY WVNSGLMTFF FLVIGLEVRR DFDLGELRER RRLTLPLLAG
IGGILVPIAI YLAFNAGRPT AVGWGVVMAT DTALALGMLA VLGPRFSDRL RNFLLTVAVV
DDLIVIAVLA IAYPEHPSPT ALFVAAGIFA LVLLIRAAGG RWGPGYLLLG VAAWLAVSES
GVDPVVVGLV MGLLTYAYAP ARTELQRAAD RFRLFREQPS PQLARSVRAG LSAALSPNDR
LQHIYHPWAS YLIVPLFALA NVGVVVDGEL LARAATSPVT LGVLFAYVVG KPAGIVIASM
LVARLSHNRF RAPVGWAAII GVGTVSGIGF TIALLIATHA LHGPALDEAK IGILVATVGA
SLTTWLVFRL AARLPPARRA RALLGVSEGI IDLMVPVDPD RDHVRGPREA PVTVVEYGDF
ECPYCGQAEP AVRELLTDFT NIRYVWRHLP LTDVHPYAQV AAEAAEAAGD QGAFWEMHDL
LLAHQGELRP ADLLGYAERL DLDLDRFREH LADRRGAVRI AEDVDGADLS SVSGTPTFFV
NGRRHHGSYN IEALSAAVTS AFAGTRLRPR DDREPDRRRE VGSEQPDEEP GT
