NHAA1_STRCO
ID NHAA1_STRCO Reviewed; 410 AA.
AC Q9S1X8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Na(+)/H(+) antiporter NhaA 1/4 {ECO:0000255|HAMAP-Rule:MF_01844};
DE AltName: Full=Sodium/proton antiporter NhaA 1 {ECO:0000255|HAMAP-Rule:MF_01844};
GN Name=nhaA1 {ECO:0000255|HAMAP-Rule:MF_01844}; OrderedLocusNames=SCO0015;
GN ORFNames=SCJ30.11c;
GN and
GN Name=nhaA4 {ECO:0000255|HAMAP-Rule:MF_01844}; OrderedLocusNames=SCO7832;
GN ORFNames=SC8E7.29;
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145;
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01844};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC family. {ECO:0000255|HAMAP-Rule:MF_01844}.
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DR EMBL; AL939104; CAB53306.1; -; Genomic_DNA.
DR EMBL; AL939132; CAC03650.1; -; Genomic_DNA.
DR PIR; T37078; T37078.
DR RefSeq; NP_624376.1; NC_003888.3.
DR RefSeq; NP_631860.1; NC_003888.3.
DR RefSeq; WP_011026778.1; NZ_VNID01000036.1.
DR AlphaFoldDB; Q9S1X8; -.
DR SMR; Q9S1X8; -.
DR TCDB; 2.A.33.1.6; the nhaa na(+):h(+) antiporter (nhaa) family.
DR GeneID; 1095436; -.
DR GeneID; 1103270; -.
DR KEGG; sco:SCO0015; -.
DR KEGG; sco:SCO7832; -.
DR PATRIC; fig|100226.15.peg.14; -.
DR eggNOG; COG3004; Bacteria.
DR HOGENOM; CLU_015803_0_0_11; -.
DR InParanoid; Q9S1X8; -.
DR OMA; LHFITND; -.
DR PhylomeDB; Q9S1X8; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 1.20.1530.10; -; 1.
DR HAMAP; MF_01844; NhaA; 1.
DR InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR InterPro; IPR004670; NhaA.
DR PANTHER; PTHR30341; PTHR30341; 1.
DR Pfam; PF06965; Na_H_antiport_1; 1.
DR TIGRFAMs; TIGR00773; NhaA; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..410
FT /note="Na(+)/H(+) antiporter NhaA 1/4"
FT /id="PRO_0000334447"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
SQ SEQUENCE 410 AA; 41975 MW; FEC7D5631FBDC133 CRC64;
MSAPSRITAA LRSDAVGGSL LIGAAVIALI WANSPLSHSY EALRSFTFGP SALHLNLSVE
TWAADGLLAV FFFIVGNELK QELVHGELRD PRRAALPIAA ALGGVAVPAL VFLAFTLGSG
GEAAGGWGIP MATGIAFAVA VLAVVGRHLP TPLRTFLLTL ATVDDMSAVL VIAVACTSGI
NFTALALAAV GLAVFGYLQN GSGRAVARVR AMVPAWLLFV PLAAVVWALM HACGVHATIA
GVVMGLLMRT RPQGAERVSP SHRAEEVLRP FSAGIALPLF ALMSAGVSLA GAGGFVTSAI
TWNVLAGLLV GKVVGIFGGT WPTSRLTSAH LNPLLGWADI AGIAVLGGIG FTVSLPIAEL
SSTSQAHLTD AKGAILLAST TAALLAALLL GRRSRHHQRL ARQAAQQATT
