NHAA2_ACICJ
ID NHAA2_ACICJ Reviewed; 449 AA.
AC A5FT52; A5FT54;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Na(+)/H(+) antiporter NhaA 2 {ECO:0000255|HAMAP-Rule:MF_01844};
DE AltName: Full=Sodium/proton antiporter NhaA 2 {ECO:0000255|HAMAP-Rule:MF_01844};
GN Name=nhaA2 {ECO:0000255|HAMAP-Rule:MF_01844};
GN OrderedLocusNames=Acry_3160/Acry_3162;
OS Acidiphilium cryptum (strain JF-5).
OG Plasmid pACRY01.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Acidiphilium.
OX NCBI_TaxID=349163;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JF-5;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.;
RT "Complete sequence of plasmid1 pACRY01 of Acidiphilium cryptum JF-5.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01844}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01844}.
CC -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC family. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- CAUTION: The sequence is interrupted by the insertion of an IS4 element
CC between positions 304 and 305. {ECO:0000305}.
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DR EMBL; CP000689; ABQ28784.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP000689; ABQ28786.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; A5FT52; -.
DR SMR; A5FT52; -.
DR EnsemblBacteria; ABQ28784; ABQ28784; Acry_3160.
DR EnsemblBacteria; ABQ28786; ABQ28786; Acry_3162.
DR KEGG; acr:Acry_3160; -.
DR KEGG; acr:Acry_3162; -.
DR HOGENOM; CLU_015803_1_2_5; -.
DR Proteomes; UP000000245; Plasmid pACRY01.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 1.20.1530.10; -; 1.
DR HAMAP; MF_01844; NhaA; 1.
DR InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR InterPro; IPR004670; NhaA.
DR PANTHER; PTHR30341; PTHR30341; 1.
DR Pfam; PF06965; Na_H_antiport_1; 1.
DR TIGRFAMs; TIGR00773; NhaA; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Plasmid; Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..449
FT /note="Na(+)/H(+) antiporter NhaA 2"
FT /id="PRO_0000334216"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
SQ SEQUENCE 449 AA; 47190 MW; A6DEE71FB2DD6E67 CRC64;
MITDQNSKPQ QGELPTTHID ALTNSFSQFL RIEATSGAVL LLATVVALTL SNSPWSDGFR
SLWETPIGIQ IGAFQFLRSL RDLINDGLMT LFFFIVALEI KREVVLGELR NPRMVALSVV
AAAGGMLVPM GLYLALQHGQ PGQHGWGVVM PTDTAFVIGC LALLGSRVPP GLRVFLLSLA
VVDDLAAILV VAVGYSRSID WTALALGAVG LVIIRGMALL GVRNIRVYFL AGAIIWLAVN
ASGIHATIVG VILGLMTPTA GWVSDQRLGE ILRKVLSYPP GDHWSGDTED NRALQVAGIA
VRETLSPVER LEAMLHPWVA FGVMPLFALA NAGVPITIKG LINPVSLAVM AGFVLGKPIG
VTAFAWLGVR TGVAIRPAGL TWGGLVGGAL LTGIGFTMAL FIAGQAFQDA TLNAAKLGIL
AASVVSSVAG LTLLCALPRS DGTLDADFH
