NHAA2_STRCO
ID NHAA2_STRCO Reviewed; 629 AA.
AC Q9S2C8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Na(+)/H(+) antiporter NhaA 2 {ECO:0000255|HAMAP-Rule:MF_01844};
DE AltName: Full=Sodium/proton antiporter NhaA 2 {ECO:0000255|HAMAP-Rule:MF_01844};
GN Name=nhaA2 {ECO:0000255|HAMAP-Rule:MF_01844}; OrderedLocusNames=SCO0285;
GN ORFNames=SCF85.13;
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145;
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01844};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the NhaA Na(+)/H(+)
CC (TC 2.A.33) antiporter family. {ECO:0000305}.
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DR EMBL; AL939104; CAB54170.1; -; Genomic_DNA.
DR PIR; T36473; T36473.
DR RefSeq; NP_624614.1; NC_003888.3.
DR RefSeq; WP_011026989.1; NZ_VNID01000014.1.
DR AlphaFoldDB; Q9S2C8; -.
DR SMR; Q9S2C8; -.
DR STRING; 100226.SCO0285; -.
DR GeneID; 1095709; -.
DR KEGG; sco:SCO0285; -.
DR PATRIC; fig|100226.15.peg.258; -.
DR eggNOG; COG1651; Bacteria.
DR eggNOG; COG3004; Bacteria.
DR HOGENOM; CLU_015803_3_0_11; -.
DR InParanoid; Q9S2C8; -.
DR OMA; WINSGLM; -.
DR PhylomeDB; Q9S2C8; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 1.20.1530.10; -; 1.
DR HAMAP; MF_01844; NhaA; 1.
DR InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR InterPro; IPR004670; NhaA.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR30341; PTHR30341; 1.
DR Pfam; PF06965; Na_H_antiport_1; 1.
DR Pfam; PF13462; Thioredoxin_4; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..629
FT /note="Na(+)/H(+) antiporter NhaA 2"
FT /id="PRO_0000334488"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT DOMAIN 443..624
FT /note="Thioredoxin"
FT REGION 1..442
FT /note="Na(+)/H(+) antiporter NhaA"
SQ SEQUENCE 629 AA; 67712 MW; 018DF55F6B37B441 CRC64;
MIIGVVSGQE PEEATPSLSA RSTVRWRTFV RTETSSAVFL LAAVAAALVW ANVGPHSYEA
VWQARFTVGF DTRRLSLTVH EWINSGLMSL FFFVVGLEAR RDFDMGELRD RRWLLLSAIA
GLGSMIVPAL IFVLVNAGRE SVHGWGTAMS TDTAFALGVL AVFGSRLPAS LRAFLLSVSV
VDDLVALLVI AVFYSDEIRL PALLVAVCAL LAIALLRLAG VRGALYCAVL SVVVWVALHE
AGVDPVVAGL AVGVLVAAYP APRGDLEQAS RLFRLFREQP TPELHRSAVQ GLDAAISPNE
RLEQRFLPWV SFGIVPLFAL ANAGIELSGP ALADAFTSPV TLGIVLGCVV GKVIGTVGSM
AAARLLSGGR LRPNVGWGSV TVGGAIAGSA FTVSLLIASL AFDGAELEEA RIGILVTLVG
AFLTSWAVTA VIGLLPERRR ARALLGDVDP LTDLAVPVDR RHDRIRGPES AVVTVVEYGD
FECPYCGQAE PVVRDLLGQE SDVRYVWRHL PLRDVHPRAQ LAAEASEAAA RQDRFWEMHD
LLLERQNALA APDLLRYAGE LGLDVERFRQ DLRDHLGARR VAEDVDSADL SRVSGTPTFF
INGRRHHGAY DIAALTRAVE LARQRALTG
