NHAA3_SALTO
ID NHAA3_SALTO Reviewed; 652 AA.
AC A4X5I0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Na(+)/H(+) antiporter NhaA 3 {ECO:0000255|HAMAP-Rule:MF_01844};
DE AltName: Full=Sodium/proton antiporter NhaA 3 {ECO:0000255|HAMAP-Rule:MF_01844};
GN Name=nhaA3 {ECO:0000255|HAMAP-Rule:MF_01844}; OrderedLocusNames=Strop_1666;
OS Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440).
OC Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC Salinispora.
OX NCBI_TaxID=369723;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-916 / DSM 44818 / CNB-440;
RX PubMed=17563368; DOI=10.1073/pnas.0700962104;
RA Udwary D.W., Zeigler L., Asolkar R.N., Singan V., Lapidus A., Fenical W.,
RA Jensen P.R., Moore B.S.;
RT "Genome sequencing reveals complex secondary metabolome in the marine
RT actinomycete Salinispora tropica.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:10376-10381(2007).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01844};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the NhaA Na(+)/H(+)
CC (TC 2.A.33) antiporter family. {ECO:0000305}.
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DR EMBL; CP000667; ABP54130.1; -; Genomic_DNA.
DR RefSeq; WP_011905561.1; NC_009380.1.
DR AlphaFoldDB; A4X5I0; -.
DR SMR; A4X5I0; -.
DR STRING; 369723.Strop_1666; -.
DR EnsemblBacteria; ABP54130; ABP54130; Strop_1666.
DR KEGG; stp:Strop_1666; -.
DR PATRIC; fig|369723.5.peg.1709; -.
DR eggNOG; COG1651; Bacteria.
DR eggNOG; COG3004; Bacteria.
DR HOGENOM; CLU_015803_3_0_11; -.
DR OMA; WINSGLM; -.
DR Proteomes; UP000000235; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 1.20.1530.10; -; 1.
DR HAMAP; MF_01844; NhaA; 1.
DR InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR InterPro; IPR004670; NhaA.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR30341; PTHR30341; 1.
DR Pfam; PF06965; Na_H_antiport_1; 1.
DR Pfam; PF13462; Thioredoxin_4; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR00773; NhaA; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..652
FT /note="Na(+)/H(+) antiporter NhaA 3"
FT /id="PRO_0000334487"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 227..249
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT DOMAIN 429..623
FT /note="Thioredoxin"
FT REGION 1..428
FT /note="Na(+)/H(+) antiporter NhaA"
FT REGION 626..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 70790 MW; 29F820CC9086B220 CRC64;
MTGEIPRGRR WSARTTRASR LNSPLRAFLH TETGSARVLL AAAVVALAWV NLDESSYESL
WGAVFSVRLG SWQVSHDLRF WVNSGLMTFF FLVIGLEVRR DFDLGELRER RRLMLPLLAG
IGGILAPIAI YLAFNAGKPT AVGWGVVMAT DTALALGMLA VLGPRFSDRL RNFLLTVAVV
DDLIVIVVLA IAYPEHPSPM ALFVAAGIFA LVLLIRAAGV RWGPGYLLLG VAAWLAVSES
GVDPVVVGLV MGLFTYAYVP ARTELQRAAD RFRLFREQPS PQLARSVRAG LASALSPNDR
LQHIYHPWAS YLIVPLFALA NVGVVVDREL LARAATSPVT LGVLFAYVVG KPAGIVIASM
LVPRLSHNQF RAPVGWAAII GVGTVSGIGF TIALLIATHA LHGPALDEAK VGILVATVGA
SLTTWLVFRL AARLAPARRA RALLGASEGI IDLMVPVDPD RDHVRGPREA PVTVVEYADF
ECPYCGQAEP AVRELLVDYT SVRYVWRHLP LTDVHPYAQM AAEAAEAAAE QGAFWEMHDL
LLAHQDELRP ADLLRYAERL DLDLDRFREH LADRRGAGRI AQDVDAADLS SVSGTPTFFV
NGRRHHGPYN IEALSAAVMS AFASARLRPE GGREPDHRSE AGSEQPDEEP GT
