NHAA3_STRCO
ID NHAA3_STRCO Reviewed; 474 AA.
AC Q9X929;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Na(+)/H(+) antiporter NhaA 3 {ECO:0000255|HAMAP-Rule:MF_01844};
DE AltName: Full=Sodium/proton antiporter NhaA 3 {ECO:0000255|HAMAP-Rule:MF_01844};
GN Name=nhaA3 {ECO:0000255|HAMAP-Rule:MF_01844}; OrderedLocusNames=SCO3564;
GN ORFNames=SCH5.27;
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145;
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01844};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01844};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01844}.
CC -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC family. {ECO:0000255|HAMAP-Rule:MF_01844}.
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DR EMBL; AL939117; CAB38501.1; -; Genomic_DNA.
DR PIR; T36685; T36685.
DR RefSeq; NP_627762.1; NC_003888.3.
DR RefSeq; WP_011029088.1; NZ_VNID01000003.1.
DR AlphaFoldDB; Q9X929; -.
DR SMR; Q9X929; -.
DR STRING; 100226.SCO3564; -.
DR GeneID; 1099000; -.
DR KEGG; sco:SCO3564; -.
DR PATRIC; fig|100226.15.peg.3620; -.
DR eggNOG; COG3004; Bacteria.
DR HOGENOM; CLU_015803_0_0_11; -.
DR InParanoid; Q9X929; -.
DR OMA; MGLMLRC; -.
DR PhylomeDB; Q9X929; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 1.20.1530.10; -; 1.
DR HAMAP; MF_01844; NhaA; 1.
DR InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR InterPro; IPR004670; NhaA.
DR PANTHER; PTHR30341; PTHR30341; 1.
DR Pfam; PF06965; Na_H_antiport_1; 1.
DR TIGRFAMs; TIGR00773; NhaA; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..474
FT /note="Na(+)/H(+) antiporter NhaA 3"
FT /id="PRO_0000334448"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01844"
SQ SEQUENCE 474 AA; 49724 MW; 258D3A9F44CB16E6 CRC64;
MTAPRTPRKA FGRLSLPERT YLADALRTET VGGVLLLVAA IAALVWANIP ALHDSYESVS
HFHFGPAALG LNLSVAHWAA DGLLAIFFFV AGIELKRELV AGDLKDPKAA ALPVVAALCG
MVVPAVVYTV TSTAGGGSLS GWAVPTATDI AFALAVLAVI GTSLPSALRA FLLTLAVVDD
LFAILIIAVF FTETLNFAAL GGAVVGLAVF WLLLRKGVRG WYVYVPLGLV IWALMYNSGV
HATIAGVAMG LMLRCHRREG EDHSPGEHIE HLVRPLSAGL AVPLFALFSA GVAITGGALA
DVFTKPETLG VVLGLVVGKT LGIFGGTWLT SRFTRASLSD DLQWADVFAV ATLAGIGFTV
SLLIGELAFE DDAAMTSEVK AAVLTGSLIA AALATVLLKI RNAKYRGMVA EEERDDDLSG
VPDIYEEDDP AYHLRVAAIY EKKAAEHRRI AEEMESARLA EVAGGAGDEG DGPA
