ID   NHAA_RICCN              Reviewed;         146 AA.
AC   Q92FX2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Putative Na(+)/H(+) antiporter NhaA homolog;
GN   Name=nhaA; OrderedLocusNames=RC1355;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. This sequence is shorter
CC       than orthologs. {ECO:0000305}.
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DR   EMBL; AE006914; AAL03893.1; -; Genomic_DNA.
DR   PIR; C97869; C97869.
DR   AlphaFoldDB; Q92FX2; -.
DR   SMR; Q92FX2; -.
DR   EnsemblBacteria; AAL03893; AAL03893; RC1355.
DR   KEGG; rco:RC1355; -.
DR   HOGENOM; CLU_080452_0_1_5; -.
DR   OMA; MMLEAVP; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341; PTHR30341; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
PE   5: Uncertain;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..146
FT                   /note="Putative Na(+)/H(+) antiporter NhaA homolog"
FT                   /id="PRO_0000334398"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   146 AA;  16352 MW;  9D7ADD568C162694 CRC64;
     MVESGIHDTL CRAIIALFIP VNIKGEFNTS FKKLENLTRP FVNYFILPLF VFMNSGILLE
     YFAFKGICSN SILALIYGII FGLFVGKQLG IMLFSYPFVK FKLCNLPSDT SWLKFYSIAI
     LGGIGFTLSL FIGSILRLRA AALQTL