ID   NHAA_RICFE              Reviewed;         286 AA.
AC   Q4UJQ7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Putative Na(+)/H(+) antiporter NhaA homolog;
GN   Name=nhaA; OrderedLocusNames=RF_1381;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. This sequence is shorter
CC       than orthologs. {ECO:0000305}.
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DR   EMBL; CP000053; AAY62232.1; -; Genomic_DNA.
DR   RefSeq; WP_011271681.1; NC_007109.1.
DR   AlphaFoldDB; Q4UJQ7; -.
DR   SMR; Q4UJQ7; -.
DR   STRING; 315456.RF_1381; -.
DR   EnsemblBacteria; AAY62232; AAY62232; RF_1381.
DR   KEGG; rfe:RF_1381; -.
DR   eggNOG; COG3004; Bacteria.
DR   HOGENOM; CLU_015803_1_0_5; -.
DR   OMA; MGLMLRC; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341; PTHR30341; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
PE   5: Uncertain;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..286
FT                   /note="Putative Na(+)/H(+) antiporter NhaA homolog"
FT                   /id="PRO_0000334399"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   286 AA;  31864 MW;  5218CA3D62C144BD CRC64;
     MVVPALIYMF FNYDKPGLIK GWAIPIATDT AFVLGILSFF SRHISLELQA FIIGFTLIDD
     AFALIILALF YTKTINTPAL LISSVIIFIL FILNYRQVKQ LFYYIIVGLL LWISMVESGI
     HGTLCGAIIA LFIPVNIKGE FNTSFKKLEN LTRPFVNYFI LPLFVFMNSG ILLEYFVFKG
     TCSNSILALV YGIIFGLFVG KQLGIMLFSY PFVKFKLCNL PSDTSWLKFY SISILGGIGF
     TLSLFIGSIT FESSCPSNSM RAAVIIGSLI SALFGVAVLK YCTSKE