ID   NHAA_RICRO              Reviewed;         266 AA.
AC   B0BVP1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Putative Na(+)/H(+) antiporter NhaA homolog;
GN   Name=nhaA; OrderedLocusNames=RrIowa_1585;
OS   Rickettsia rickettsii (strain Iowa).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=452659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Iowa;
RX   PubMed=18025092; DOI=10.1128/iai.00952-07;
RA   Ellison D.W., Clark T.R., Sturdevant D.E., Virtaneva K., Porcella S.F.,
RA   Hackstadt T.;
RT   "Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and
RT   avirulent Rickettsia rickettsii Iowa.";
RL   Infect. Immun. 76:542-550(2008).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. This sequence is shorter
CC       than orthologs. {ECO:0000305}.
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DR   EMBL; CP000766; ABY73301.1; -; Genomic_DNA.
DR   RefSeq; WP_012151462.1; NC_010263.3.
DR   AlphaFoldDB; B0BVP1; -.
DR   SMR; B0BVP1; -.
DR   STRING; 452659.RrIowa_1585; -.
DR   EnsemblBacteria; ABY73301; ABY73301; RrIowa_1585.
DR   GeneID; 45539820; -.
DR   KEGG; rrj:RrIowa_1585; -.
DR   eggNOG; COG3004; Bacteria.
DR   HOGENOM; CLU_015803_1_0_5; -.
DR   OMA; WHTPFGF; -.
DR   Proteomes; UP000000796; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom_sf.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341; PTHR30341; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
PE   5: Uncertain;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..266
FT                   /note="Putative Na(+)/H(+) antiporter NhaA homolog"
FT                   /id="PRO_0000334401"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   266 AA;  29808 MW;  B242711A1B5DB522 CRC64;
     MNIKKLILPA AAALGGVVIP VLIYMFFNYG KPELIKGWAI PIATDTAFVL GILSFFSRHI
     SLELRAFIIG FSLIDDAFAL IILALFYAKT INTLALLISS IIIFILFILN YRQVKQLFYY
     IIVGLLLCIS MVKSGIHDTL CRAIIALFIP VNIKGEFNTS FKKLENLIRP FVNYFILPLF
     VFMNSGILLE YFAFKGICSN SILALIYGII FGLSVGKQLG IMLFSYPFVK FKLCNLPSDT
     SWLKFYSIAI LRGIGFTLSL FIGSNV