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NHAB_ALTMD
ID   NHAB_ALTMD              Reviewed;         524 AA.
AC   B4RU97; F2G6T5;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Na(+)/H(+) antiporter NhaB {ECO:0000255|HAMAP-Rule:MF_01599};
DE   AltName: Full=Sodium/proton antiporter NhaB {ECO:0000255|HAMAP-Rule:MF_01599};
GN   Name=nhaB {ECO:0000255|HAMAP-Rule:MF_01599};
GN   OrderedLocusNames=MADE_1012165;
OS   Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep
OS   ecotype).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Alteromonadaceae; Alteromonas/Salinimonas group; Alteromonas.
OX   NCBI_TaxID=1774373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype;
RX   PubMed=18670397; DOI=10.1038/ismej.2008.74;
RA   Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S.,
RA   Johnson J., Friedman R., Rodriguez-Valera F.;
RT   "Comparative genomics of two ecotypes of the marine planktonic copiotroph
RT   Alteromonas macleodii suggests alternative lifestyles associated with
RT   different kinds of particulate organic matter.";
RL   ISME J. 2:1194-1212(2008).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC       external protons. {ECO:0000255|HAMAP-Rule:MF_01599}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out);
CC         Xref=Rhea:RHEA:29247, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01599};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29248;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01599};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01599}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01599}.
CC   -!- SIMILARITY: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter
CC       family. {ECO:0000255|HAMAP-Rule:MF_01599}.
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DR   EMBL; CP001103; AEA98569.1; -; Genomic_DNA.
DR   RefSeq; WP_012518887.1; NC_011138.3.
DR   AlphaFoldDB; B4RU97; -.
DR   SMR; B4RU97; -.
DR   EnsemblBacteria; AEA98569; AEA98569; MADE_1012165.
DR   GeneID; 56342911; -.
DR   KEGG; amc:MADE_1012165; -.
DR   HOGENOM; CLU_041110_0_0_6; -.
DR   Proteomes; UP000001870; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   HAMAP; MF_01599; NhaB; 1.
DR   InterPro; IPR004671; Na+/H+_antiporter_NhaB.
DR   PANTHER; PTHR43302:SF1; PTHR43302:SF1; 1.
DR   Pfam; PF06450; NhaB; 1.
DR   TIGRFAMs; TIGR00774; NhaB; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..524
FT                   /note="Na(+)/H(+) antiporter NhaB"
FT                   /id="PRO_0000381766"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
SQ   SEQUENCE   524 AA;  57346 MW;  0E2D09FD8B6DCD4E CRC64;
     MQTSMIAAIY KNFLGHAPDW YKKTIIAFLI VNPFIFMVDP YIAGWTLVIQ FIFTLAMALK
     CYPLQPGGLL LIEAMFIGMT SPGHMMHEIE VNLEVLLLLV FMVAGIYFMK DLLMFLFTKL
     VIKVRNKLIL SLSFIFASAF LSAFLDALTV VAVIISVGLG FYSIYHKVAS GKEFHSDHDH
     TSDDELGSHD LEDFRAFLRN LMMHSAVGTA LGGVMTMVGE PQNLIIADKA GWDFVEFFIR
     MAPVTLPVFV FGLLTTVVLE KTGTFSYGAK LPSAVRQILV DYNDHMDKGR SKRETAKLVV
     QALIGIWLIV GLATHMASVG LIGLSVIVLA TSMSGVIEEH ALGKAFEEAL PFTALLCVFF
     GVVAVIIDQG LFQPVIHWVL SFEGETQMVM FYLANGVLSM VSDNVFVGSV YITEVTAALE
     AGQITRDQYD MLAVAINTGT NLPSVATPNG QAAFLFLLTS AIAPLLRLSY GRMVMMALPY
     TIVLTIVGLV ATYIGLADAT QVLYDMHLIE HHTAVEAGAQ AVGH
 
 
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