NHAB_ALTMD
ID NHAB_ALTMD Reviewed; 524 AA.
AC B4RU97; F2G6T5;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Na(+)/H(+) antiporter NhaB {ECO:0000255|HAMAP-Rule:MF_01599};
DE AltName: Full=Sodium/proton antiporter NhaB {ECO:0000255|HAMAP-Rule:MF_01599};
GN Name=nhaB {ECO:0000255|HAMAP-Rule:MF_01599};
GN OrderedLocusNames=MADE_1012165;
OS Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep
OS ecotype).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Alteromonas/Salinimonas group; Alteromonas.
OX NCBI_TaxID=1774373;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype;
RX PubMed=18670397; DOI=10.1038/ismej.2008.74;
RA Ivars-Martinez E., Martin-Cuadrado A.-B., D'Auria G., Mira A., Ferriera S.,
RA Johnson J., Friedman R., Rodriguez-Valera F.;
RT "Comparative genomics of two ecotypes of the marine planktonic copiotroph
RT Alteromonas macleodii suggests alternative lifestyles associated with
RT different kinds of particulate organic matter.";
RL ISME J. 2:1194-1212(2008).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000255|HAMAP-Rule:MF_01599}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out);
CC Xref=Rhea:RHEA:29247, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01599};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29248;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01599};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01599}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01599}.
CC -!- SIMILARITY: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter
CC family. {ECO:0000255|HAMAP-Rule:MF_01599}.
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DR EMBL; CP001103; AEA98569.1; -; Genomic_DNA.
DR RefSeq; WP_012518887.1; NC_011138.3.
DR AlphaFoldDB; B4RU97; -.
DR SMR; B4RU97; -.
DR EnsemblBacteria; AEA98569; AEA98569; MADE_1012165.
DR GeneID; 56342911; -.
DR KEGG; amc:MADE_1012165; -.
DR HOGENOM; CLU_041110_0_0_6; -.
DR Proteomes; UP000001870; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR HAMAP; MF_01599; NhaB; 1.
DR InterPro; IPR004671; Na+/H+_antiporter_NhaB.
DR PANTHER; PTHR43302:SF1; PTHR43302:SF1; 1.
DR Pfam; PF06450; NhaB; 1.
DR TIGRFAMs; TIGR00774; NhaB; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..524
FT /note="Na(+)/H(+) antiporter NhaB"
FT /id="PRO_0000381766"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01599"
SQ SEQUENCE 524 AA; 57346 MW; 0E2D09FD8B6DCD4E CRC64;
MQTSMIAAIY KNFLGHAPDW YKKTIIAFLI VNPFIFMVDP YIAGWTLVIQ FIFTLAMALK
CYPLQPGGLL LIEAMFIGMT SPGHMMHEIE VNLEVLLLLV FMVAGIYFMK DLLMFLFTKL
VIKVRNKLIL SLSFIFASAF LSAFLDALTV VAVIISVGLG FYSIYHKVAS GKEFHSDHDH
TSDDELGSHD LEDFRAFLRN LMMHSAVGTA LGGVMTMVGE PQNLIIADKA GWDFVEFFIR
MAPVTLPVFV FGLLTTVVLE KTGTFSYGAK LPSAVRQILV DYNDHMDKGR SKRETAKLVV
QALIGIWLIV GLATHMASVG LIGLSVIVLA TSMSGVIEEH ALGKAFEEAL PFTALLCVFF
GVVAVIIDQG LFQPVIHWVL SFEGETQMVM FYLANGVLSM VSDNVFVGSV YITEVTAALE
AGQITRDQYD MLAVAINTGT NLPSVATPNG QAAFLFLLTS AIAPLLRLSY GRMVMMALPY
TIVLTIVGLV ATYIGLADAT QVLYDMHLIE HHTAVEAGAQ AVGH