NHAH_HALAD
ID NHAH_HALAD Reviewed; 403 AA.
AC B0LJC9;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Na(+)/H(+) antiporter NhaH;
DE AltName: Full=Sodium/proton antiporter NhaH;
GN Name=nhaH;
OS Halobacillus aidingensis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Halobacillus.
OX NCBI_TaxID=240303;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES,
RP AND SUBCELLULAR LOCATION.
RC STRAIN=DSM 18198 / JCM 12771 / AD-6;
RX PubMed=18758732; DOI=10.1007/s12275-008-0009-2;
RA Zou Y.J., Yang L.F., Wang L., Yang S.S.;
RT "Cloning and characterization of a Na+/H+ antiporter gene of the moderately
RT halophilic bacterium Halobacillus aidingensis AD-6T.";
RL J. Microbiol. 46:415-421(2008).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. Can also transport lithium.
CC {ECO:0000269|PubMed:18758732}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC pH dependence:
CC Optimum pH is 8.0 for sodium and lithium transport. Exhibits
CC Na(+)/H(+) and Li(+)/H(+) antiporter activity between pH 6.5 and 9.5.
CC {ECO:0000269|PubMed:18758732};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18758732};
CC Multi-pass membrane protein {ECO:0000269|PubMed:18758732}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000305}.
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DR EMBL; EU159451; ABX57744.1; -; Genomic_DNA.
DR AlphaFoldDB; B0LJC9; -.
DR SMR; B0LJC9; -.
DR STRING; 240303.SAMN05421677_102341; -.
DR TCDB; 2.A.36.6.10; the monovalent cation:proton antiporter-1 (cpa1) family.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR PANTHER; PTHR10110; PTHR10110; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 1: Evidence at protein level;
KW Antiport; Cell membrane; Ion transport; Membrane; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..403
FT /note="Na(+)/H(+) antiporter NhaH"
FT /id="PRO_0000423858"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 403 AA; 43575 MW; 8D7FC3F218DD1E09 CRC64;
MHGFHDVFIQ ILLLLAISVT VIAIAKLLKE PDSVALVLVG LVLGLTQLPF IEEAESYITQ
SEVFQATVIS LFLPILLGDA TLKLPFHHLF SQKKTVMGLA FLGTFISSLT IGAASYFLLD
LPLAVAFTFA ALMSATDPIS VLSIFKSLGV KQKMSTIMEG ESLFNDGIAV VLFKIASIYL
LTYIEMGWAG LGSGVFMFLK FAVGGALVGL ILGYVFSQVI RVYDDYPLEV AFSALLFFGS
YFIAEHFHTS GVIAVVVGGF VFGDYGAKIG MSEETKTNLN TFWDSVTLLA NALIFLMVGL
EIRNIDLAGN WGYIVGAIAI VLVGRTIAVY IGTGWIKELS SKERILINWG GLRGSLSIAL
ALSLPMDFDG REQVLLLTFS VVLFSLIVQG LTLKPVIKKL GLA
