ID   NHAK_BACP2              Reviewed;         671 AA.
AC   A8FHE3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Sodium, potassium, lithium and rubidium/H(+) antiporter;
GN   Name=nhaK; OrderedLocusNames=BPUM_3006;
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=315750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032;
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA   Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA   Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA   Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA   Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA   Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA   Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
CC   -!- FUNCTION: Transporter involved in the efflux of sodium, potassium,
CC       lithium and rubidium. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP000813; ABV63660.1; -; Genomic_DNA.
DR   RefSeq; WP_012011255.1; NZ_VEIC01000015.1.
DR   AlphaFoldDB; A8FHE3; -.
DR   SMR; A8FHE3; -.
DR   STRING; 315750.BPUM_3006; -.
DR   PRIDE; A8FHE3; -.
DR   EnsemblBacteria; ABV63660; ABV63660; BPUM_3006.
DR   KEGG; bpu:BPUM_3006; -.
DR   eggNOG; COG0025; Bacteria.
DR   HOGENOM; CLU_005912_6_2_9; -.
DR   OMA; AFHTERE; -.
DR   OrthoDB; 1194802at2; -.
DR   Proteomes; UP000001355; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   TIGRFAMs; TIGR00831; a_cpa1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Lithium; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Sodium; Sodium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..671
FT                   /note="Sodium, potassium, lithium and rubidium/H(+)
FT                   antiporter"
FT                   /id="PRO_0000337073"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   671 AA;  75961 MW;  5BE22E3968F622EF CRC64;
     MEIFLAVLVL LALIASSNII NRFVPFIPVP LIQVGLGILV AAFPSGLHIS LNPELFFVLF
     IAPLLFNDGK RTPRDELWKL RAPILLLALG LVFATVIVAG YTIHWMIPSI PLPAAFALAA
     ILSPTDVVAV SALSSRVNMP KGIMRLLEGE GLMNDASGLV AFKFAIAATV TGAFSIAEAS
     FSFVLIAAGG LLTGFILSFF IIRFRYFLRR LGMDDVTMHI ILQILTPFVI YLAAEEIGVS
     GILAVVAGGV THAIEQDRME ANLAKLQIAS SNTWNIILFI LNGLVFVILG LQIPDVSTVI
     FQDEAFNNMQ VITYILIITL CLMILRFLWV WLFWAGKWSA TKKQNVKKPK LRASMLMTFS
     GVRGAVTLAG AFSIPFTLAD GSPFPERHLI IFLAAGVILC TLILASVLLP LLSEKKDKQI
     AVDLDTKIQH AKRKLLRSAI KTLREGMNED NREVSLALIN DYRMKLRNIQ REPYQFGMRR
     QEKKIRLHGI KAEQMKLQQL IEEEKIDQQE AYELQERFHE LEMLYSNSFK IRFSKVKFLR
     LLQWLQLWRP NQLVSSGILE NEDSYKQIRK KTAEAAVDSI KQHMNDENKQ TCHQVIGFYN
     QVIYRCEHGP SFFQQKDRSF DRKKKELNFQ AVQTIRNEIQ TLYENGEINR DIAHHLREYI
     NDMEAVLLTN T