ID   NHAK_BACVZ              Reviewed;         671 AA.
AC   A7Z8R4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Sodium, potassium, lithium and rubidium/H(+) antiporter;
GN   Name=nhaK; OrderedLocusNames=RBAM_030590;
OS   Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)
OS   (Bacillus amyloliquefaciens subsp. plantarum).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus amyloliquefaciens group.
OX   NCBI_TaxID=326423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42;
RX   PubMed=17704766; DOI=10.1038/nbt1325;
RA   Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K.,
RA   Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H.,
RA   Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H.,
RA   Strittmatter A., Gottschalk G., Borriss R.;
RT   "Comparative analysis of the complete genome sequence of the plant growth-
RT   promoting bacterium Bacillus amyloliquefaciens FZB42.";
RL   Nat. Biotechnol. 25:1007-1014(2007).
CC   -!- FUNCTION: Transporter involved in the efflux of sodium, potassium,
CC       lithium and rubidium. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP000560; ABS75390.1; -; Genomic_DNA.
DR   RefSeq; WP_012118437.1; NC_009725.2.
DR   AlphaFoldDB; A7Z8R4; -.
DR   SMR; A7Z8R4; -.
DR   STRING; 326423.RBAM_030590; -.
DR   EnsemblBacteria; ABS75390; ABS75390; RBAM_030590.
DR   KEGG; bay:RBAM_030590; -.
DR   HOGENOM; CLU_005912_6_2_9; -.
DR   OMA; TYNTEHC; -.
DR   Proteomes; UP000001120; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   InterPro; IPR002014; VHS_dom.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   TIGRFAMs; TIGR00831; a_cpa1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Lithium; Membrane; Potassium;
KW   Potassium transport; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..671
FT                   /note="Sodium, potassium, lithium and rubidium/H(+)
FT                   antiporter"
FT                   /id="PRO_0000337072"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   671 AA;  75115 MW;  C663BA0FCDAD8063 CRC64;
     MDIFLVVLVL LTIIAISNIV NRFVPFIPVP LIQVALGIIA ASFPQGLHFE LNTELFFVLF
     IAPLLFNDGK RTPRAELWNL RAPILLLALG LVFATVIVGG YTIHWMIPSI PLAAAFGLAA
     ILSPTDVVAV SALSGRVKMP KGILRLLEGE GLMNDASGLV AFKFAIAAAV TGAFSLAQAA
     FSFVLISAGG LLSGVVISFL IIRFRLFLRR LGMQDVTMHM LIQILTPFVI YLAAEEIGVS
     GILAVVAGGI THAVEQDRLE STMVKLQIVS SSTWNIILFI LNGLVFVILG AQIPDVVSVI
     FNDTAFNNMM VIGYIIVITL TLMILRFLWV LFFWNGKWFF NKDQSIYKPG LRSTLLISVS
     GVRGAVTLAG SFSIPYVLSD GSPFPERNLI LFLAAGVIMC TLVLATIVLP ILTDKPEDNV
     KEKKVKLLTA RRKLIKAALT AIKENMNETN KTASFAVIAE YNEKMKNLRF QQFTVKNRTK
     KDERKVRAQG IQAEQEELLR LIERGDIPEE TADSLQERFD ELEVLYTNPF KVGLSKKKLK
     RLMYWIFFGE QKKPEMTILN EEGLIRATRV KTAKAAIESL KKHMTEENKD VTLAVISFYN
     HLIFRLGHSY HEQNPSRRFE NQKLEIKLRA VQAIRNEIQT LFEEREISRD MSHELRQYIN
     DVEAAMLDGD E