A1BG_MOUSE
ID A1BG_MOUSE Reviewed; 512 AA.
AC Q19LI2;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Alpha-1B-glycoprotein;
DE AltName: Full=Alpha-1-B glycoprotein;
DE Flags: Precursor;
GN Name=A1bg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=16723264; DOI=10.1016/j.ghir.2006.03.011;
RA Tiong J.D.R., Gosney E., Ding J., Chin E., Kopchick J.J.;
RT "A liver specific gene that is expressed in growth hormone transgenic mice
RT and in normal female mice as a function of age.";
RL Growth Horm. IGF Res. 16:145-156(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-89 AND ASN-485.
RC STRAIN=C57BL/6J; TISSUE=Plasma;
RX PubMed=17330941; DOI=10.1021/pr0604559;
RA Bernhard O.K., Kapp E.A., Simpson R.J.;
RT "Enhanced analysis of the mouse plasma proteome using cysteine-containing
RT tryptic glycopeptides.";
RL J. Proteome Res. 6:987-995(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with CRISP3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the liver hepatocytes of male and
CC female GH transgenic mice and in the liver of female, but not of male,
CC non-transgenic mice. {ECO:0000269|PubMed:16723264}.
CC -!- DEVELOPMENTAL STAGE: Expressed at 3-days but not at 11-days of age in
CC both female and male GH transgenic mice. Expression in the normal
CC female mice begins as early as 2 months and is detected at much higher
CC levels at 5, 12 and 24 months while at 30 months, expression is lower.
CC {ECO:0000269|PubMed:16723264}.
CC -!- INDUCTION: Induced in hepatocytes during the proliferative phase of
CC liver regeneration. Induction requires a continuous pattern of GH
CC (growth hormaone) secretion and an intact GH-GH receptor-signaling
CC complex. {ECO:0000269|PubMed:16723264}.
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DR EMBL; DQ520794; ABF68843.1; -; mRNA.
DR EMBL; CH466545; EDL29338.1; -; Genomic_DNA.
DR CCDS; CCDS37085.1; -.
DR RefSeq; NP_001074536.1; NM_001081067.1.
DR AlphaFoldDB; Q19LI2; -.
DR SMR; Q19LI2; -.
DR STRING; 10090.ENSMUSP00000094151; -.
DR GlyGen; Q19LI2; 7 sites.
DR iPTMnet; Q19LI2; -.
DR PhosphoSitePlus; Q19LI2; -.
DR SwissPalm; Q19LI2; -.
DR CPTAC; non-CPTAC-3518; -.
DR MaxQB; Q19LI2; -.
DR PaxDb; Q19LI2; -.
DR PeptideAtlas; Q19LI2; -.
DR PRIDE; Q19LI2; -.
DR ProteomicsDB; 285743; -.
DR Antibodypedia; 3284; 448 antibodies from 37 providers.
DR DNASU; 117586; -.
DR Ensembl; ENSMUST00000096418; ENSMUSP00000094151; ENSMUSG00000022347.
DR GeneID; 117586; -.
DR KEGG; mmu:117586; -.
DR UCSC; uc007vyd.1; mouse.
DR CTD; 1; -.
DR MGI; MGI:2152878; A1bg.
DR VEuPathDB; HostDB:ENSMUSG00000022347; -.
DR eggNOG; ENOG502RYEX; Eukaryota.
DR GeneTree; ENSGT01050000244944; -.
DR HOGENOM; CLU_042929_1_0_1; -.
DR InParanoid; Q19LI2; -.
DR OMA; RCRYRSW; -.
DR OrthoDB; 1327293at2759; -.
DR PhylomeDB; Q19LI2; -.
DR TreeFam; TF336644; -.
DR Reactome; R-MMU-114608; Platelet degranulation.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 117586; 3 hits in 73 CRISPR screens.
DR ChiTaRS; A1bg; mouse.
DR PRO; PR:Q19LI2; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q19LI2; protein.
DR Bgee; ENSMUSG00000022347; Expressed in primary oocyte and 18 other tissues.
DR ExpressionAtlas; Q19LI2; baseline and differential.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR Gene3D; 2.60.40.10; -; 5.
DR InterPro; IPR016332; A1B_glyco/leuk_Ig-like_rcpt.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR Pfam; PF13895; Ig_2; 1.
DR PIRSF; PIRSF001979; Alpha_1B_glycoprot_prd; 1.
DR SMART; SM00409; IG; 3.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..512
FT /note="Alpha-1B-glycoprotein"
FT /id="PRO_0000355542"
FT DOMAIN 22..126
FT /note="Ig-like V-type 1"
FT DOMAIN 127..219
FT /note="Ig-like V-type 2"
FT DOMAIN 220..312
FT /note="Ig-like V-type 3"
FT DOMAIN 313..415
FT /note="Ig-like V-type 4"
FT DOMAIN 416..512
FT /note="Ig-like V-type 5"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17330941"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 369
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 389
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 485
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17330941"
FT DISULFID 49..96
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 153..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 245..292
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 343..392
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 441..488
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 512 AA; 56554 MW; B511CDCF0D26677A CRC64;
MSLLATVLLL WGFTLGPGNT LMLDSGSEPK LWAEPQSLLE PWANLTLVCA VDLPTKVFEL
IQNGWFLSQV RLETQVLSYR FSLGAITSNN SGIYRCRCGV EPPVDIHLPA LNKWTMLSNA
VEVTGKEPLP RPLAHADPVD WITPGGLPVY VMCQVAMRGV TYLLRQEGVD GVQKPDVQHK
GTAGFLIYKP GNYSCSYLTH AAGEPSEPSD IVTIKMYASQ APPTLCLMGN YLMIYPQKTY
ETLACKAPRN AAEFQLRQGG KVLKIHGFSP TRDAILYYVN LKELDNPGPF TCRYRMHKYM
HVWSEDSKPV ELMWSDETLQ APVLTAEPSS RDLEPGSTVQ LRCTAPVSGL RFGLQRQGKP
ELVVVQMLNS SGTEAVFELH NISTIDSGNY SCIYMEQAPP FSGSSSSEPV ELRVNGPPPK
PRLEALWKST VHLGQEAIFR CHGHVPRVSM ELVREGFKTP FAVASTRSTS AYLKLLFVGP
QHAGNYSCRY TALPPFTFES GISDPVEVIV EG
