位置:首页 > 蛋白库 > NHAP2_YERP3
NHAP2_YERP3
ID   NHAP2_YERP3             Reviewed;         575 AA.
AC   A7FGZ9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=K(+)/H(+) antiporter NhaP2 {ECO:0000255|HAMAP-Rule:MF_01075};
DE   AltName: Full=Potassium/proton antiporter NhaP2 {ECO:0000255|HAMAP-Rule:MF_01075};
GN   Name=nhaP2 {ECO:0000255|HAMAP-Rule:MF_01075}; Synonyms=cvrA;
GN   OrderedLocusNames=YpsIP31758_1549;
OS   Yersinia pseudotuberculosis serotype O:1b (strain IP 31758).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP 31758;
RX   PubMed=17784789; DOI=10.1371/journal.pgen.0030142;
RA   Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G.,
RA   Fayolle C., Lindler L.E., Carniel E., Ravel J.;
RT   "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the
RT   causative agent of Far East scarlet-like fever.";
RL   PLoS Genet. 3:1508-1523(2007).
CC   -!- FUNCTION: K(+)/H(+) antiporter that extrudes potassium in exchange for
CC       external protons and maintains the internal concentration of potassium
CC       under toxic levels. {ECO:0000255|HAMAP-Rule:MF_01075}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out);
CC         Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01075};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29468;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01075};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01075}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01075}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. NhaP2 subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_01075}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000720; ABS47157.1; -; Genomic_DNA.
DR   RefSeq; WP_011192618.1; NC_009708.1.
DR   AlphaFoldDB; A7FGZ9; -.
DR   SMR; A7FGZ9; -.
DR   EnsemblBacteria; ABS47157; ABS47157; YpsIP31758_1549.
DR   GeneID; 66845081; -.
DR   KEGG; ypi:YpsIP31758_1549; -.
DR   HOGENOM; CLU_005912_9_2_6; -.
DR   OMA; QIGMFVL; -.
DR   Proteomes; UP000002412; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0015386; F:potassium:proton antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006884; P:cell volume homeostasis; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.30.70.1450; -; 1.
DR   HAMAP; MF_01075; NhaP2; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR030151; NhaP.
DR   InterPro; IPR023729; NhaP2.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   PANTHER; PTHR32507:SF7; PTHR32507:SF7; 1.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF116726; SSF116726; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51202; RCK_C; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Potassium; Potassium transport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..575
FT                   /note="K(+)/H(+) antiporter NhaP2"
FT                   /id="PRO_1000064678"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        244..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
FT   DOMAIN          403..485
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01075"
SQ   SEQUENCE   575 AA;  61636 MW;  E4D4599F165D3DDB CRC64;
     MDAITINSLF LVGAVLVAAS ILLSSFSSRL GIPILVIFLA IGMLAGTDGL GGIAFDNYPA
     AYLVSNLALA VILLDGGMRT RASSFRVALW PALSLATFGV IITAGLTGLV AAWLFNLDII
     QGLLIGAIIG STDAAAVFSL LGGKGLNERV SATLEIESGS NDPMAVFLTV TLIAMIAAGE
     TSLSWMFLVH LIQQFGLGII IGLLGGGLLL LLINRMELAN GLYPLLAVSG GILVFALATA
     LNGSGILAVY LCGLLLGNRP IRNRAGILQT FDGLAWLSQI GMFLVLGLLL NPSDLLPIAI
     PALLLSLWMI LFARPLSVFI GLLPFRSFNL RERVFISWVG LRGAVPVILA VFPMMAGLPN
     ANLFFNVAFF VVLVSLLLQG TTLSFAARKA KLVVPPTLAP VSRIGLDIDM NNQWEQFIYQ
     LSCDKWCIGA TLRDLKMPQG TRIAALFRGK DLLHPTGSTR LKEGDILCVI GQEHDLPALG
     KLFSQSPNIQ LDERFFGDFI LDADAKLQDI SQIYGLNLEP TVDKQQTLGQ FVLYLFGGEP
     VIGDQIEWDG LTWTIAEMES DRVSRVGVKI VTDKA
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024