ID   NHAR_VIBCH              Reviewed;         296 AA.
AC   P52692; Q9JMP8;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Transcriptional activator protein NhaR;
DE   AltName: Full=Na(+)/H(+) antiporter regulatory protein;
GN   Name=nhaR; Synonyms=hlyT; OrderedLocusNames=VC_0677;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Classical Inaba Z17561 / Serotype O1;
RX   PubMed=8231807; DOI=10.1111/j.1365-2958.1993.tb01735.x;
RA   Williams S.G., Attridge S.R., Manning P.A.;
RT   "The transcriptional activator HlyU of Vibrio cholerae: nucleotide sequence
RT   and role in virulence gene expression.";
RL   Mol. Microbiol. 9:751-760(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=El Tor O17 / Serotype O1;
RX   PubMed=9457888; DOI=10.1128/jb.180.3.762-765.1998;
RA   Williams S.G., Carmel-Harel O., Manning P.A.;
RT   "A functional homolog of Escherichia coli NhaR in Vibrio cholerae.";
RL   J. Bacteriol. 180:762-765(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Plays a role in the positive regulation of NhaA.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; X66866; CAA47335.1; -; Genomic_DNA.
DR   EMBL; AJ002395; CAA05371.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF93842.1; -; Genomic_DNA.
DR   PIR; S37312; S37312.
DR   RefSeq; NP_230326.1; NC_002505.1.
DR   RefSeq; WP_000018876.1; NZ_LT906614.1.
DR   AlphaFoldDB; P52692; -.
DR   SMR; P52692; -.
DR   STRING; 243277.VC_0677; -.
DR   DNASU; 2615466; -.
DR   EnsemblBacteria; AAF93842; AAF93842; VC_0677.
DR   GeneID; 57739392; -.
DR   KEGG; vch:VC_0677; -.
DR   PATRIC; fig|243277.26.peg.649; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_9_0_6; -.
DR   OMA; WLNYHHL; -.
DR   BioCyc; VCHO:VC0677-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:2000142; P:regulation of DNA-templated transcription, initiation; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..296
FT                   /note="Transcriptional activator protein NhaR"
FT                   /id="PRO_0000105691"
FT   DOMAIN          1..61
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        21..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   296 AA;  33560 MW;  C7830B4B532DBC0C CRC64;
     MSHLNYNHLY YFWMVCKQGS VTKAADALFL TPQTVTGQIK ALEDRLDGKL TKRNGRSIEP
     TELGQLVFKY ADRMFGLSYE MLDIVNYSQR SNLLFDVGVA DALSKRLVSK ILLTSVPGDN
     RIHLRCFEST HEMLLEQLAQ HKLDMILSDC PVDSSQSPGL FSKKLGESRM SFFSFGDVDF
     APFPAVLQSK KLLVPGSRTA MGRKVRQWFD RQGLQPHILG EFDDSALMKA FAIYHSDAVF
     MAPSFYVSEV DAESSLKLIG HVDEIKEEYY VIFAERMIQH PAVKNVCDAD FTNLFL