ID   NHAS4_SYNY3             Reviewed;         410 AA.
AC   P72973;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Na(+)/H(+) antiporter NhaS4;
DE   AltName: Full=Sodium/proton antiporter NhaS4;
GN   Name=nhaS4; OrderedLocusNames=slr1595;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
RN   [2]
RP   GENE NAME.
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=11157951; DOI=10.1128/jb.183.4.1376-1384.2001;
RA   Inaba M., Sakamoto A., Murata N.;
RT   "Functional expression in Escherichia coli of low-affinity and high-
RT   affinity Na(+)(Li(+))/H(+) antiporters of Synechocystis.";
RL   J. Bacteriol. 183:1376-1384(2001).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=11996656; DOI=10.1023/a:1015281906254;
RA   Elanskaya I.V., Karandashova I.V., Bogachev A.V., Hagemann M.;
RT   "Functional analysis of the Na+/H+ antiporter encoding genes of the
RT   cyanobacterium Synechocystis PCC 6803.";
RL   Biochemistry (Mosc.) 67:432-440(2002).
CC   -!- FUNCTION: Na(+)/H(+) antiporter. {ECO:0000305|PubMed:11996656}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA16991.1; -; Genomic_DNA.
DR   PIR; S74951; S74951.
DR   AlphaFoldDB; P72973; -.
DR   SMR; P72973; -.
DR   IntAct; P72973; 4.
DR   STRING; 1148.1652066; -.
DR   PaxDb; P72973; -.
DR   EnsemblBacteria; BAA16991; BAA16991; BAA16991.
DR   KEGG; syn:slr1595; -.
DR   eggNOG; COG0475; Bacteria.
DR   InParanoid; P72973; -.
DR   OMA; SPLFFVW; -.
DR   PhylomeDB; P72973; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Antiport; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..410
FT                   /note="Na(+)/H(+) antiporter NhaS4"
FT                   /id="PRO_0000423930"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   410 AA;  44753 MW;  B1D46418C991BF7E CRC64;
     MDTNTLLLIL ANIIVIIGLA RLIGLLFARF QQPPVIGEII AGIMLGPSLL GLLSPALEKS
     FFPATTQPFL YLLSEIGLIF YMFLVGLELN PQYLRQKLKV AILTSNVSIF FPFVLGIVLS
     FFVLYSLNQP NKTSFIPFAL FIGAAMSITA FPVLARILKD TGLDKTPLGT LGLTCASVDD
     ISAWCLLAIA IAVTRTDNIF GAFPTLLGII VYTVFMVTLG RKFFKYILRN YGQKNYLSQG
     LLTFIYIMVI LSAMLTEWIG IDVIFGGFIL GAILPKNTNL STELATKTED FVSTFLLPIF
     FAYSGLSTDL GLLNKPYLWA VCALVVAAAI AGKYCGVYVT TRALGVEKQE AKALGWLMNT
     RGLTELIILN VGLKLGVISP VIFTMFVIMA IITTIITSPL VVKIYPAPAH