ID   NHAS5_SYNY3             Reviewed;         698 AA.
AC   Q55736;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Na(+)/H(+) antiporter NhaS5;
DE   AltName: Full=Sodium/proton antiporter NhaS5;
GN   Name=nhaS5; Synonyms=napA; OrderedLocusNames=slr0415;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
RN   [2]
RP   GENE NAME.
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=11157951; DOI=10.1128/jb.183.4.1376-1384.2001;
RA   Inaba M., Sakamoto A., Murata N.;
RT   "Functional expression in Escherichia coli of low-affinity and high-
RT   affinity Na(+)(Li(+))/H(+) antiporters of Synechocystis.";
RL   J. Bacteriol. 183:1376-1384(2001).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=11996656; DOI=10.1023/a:1015281906254;
RA   Elanskaya I.V., Karandashova I.V., Bogachev A.V., Hagemann M.;
RT   "Functional analysis of the Na+/H+ antiporter encoding genes of the
RT   cyanobacterium Synechocystis PCC 6803.";
RL   Biochemistry (Mosc.) 67:432-440(2002).
CC   -!- FUNCTION: Na(+)/H(+) antiporter. {ECO:0000305|PubMed:11996656}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA10378.1; -; Genomic_DNA.
DR   PIR; S76532; S76532.
DR   AlphaFoldDB; Q55736; -.
DR   SMR; Q55736; -.
DR   IntAct; Q55736; 3.
DR   STRING; 1148.1001647; -.
DR   PaxDb; Q55736; -.
DR   EnsemblBacteria; BAA10378; BAA10378; BAA10378.
DR   KEGG; syn:slr0415; -.
DR   eggNOG; COG0475; Bacteria.
DR   eggNOG; COG0589; Bacteria.
DR   InParanoid; Q55736; -.
DR   OMA; NALFIPY; -.
DR   PhylomeDB; Q55736; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR006016; UspA.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF00582; Usp; 2.
PE   3: Inferred from homology;
KW   Antiport; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..698
FT                   /note="Na(+)/H(+) antiporter NhaS5"
FT                   /id="PRO_0000423931"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   698 AA;  75548 MW;  C7D318D229E10446 CRC64;
     MDGLFAPIPS NPLIDFTILL LVTLILPPIF ERLKLPGLVG LLFAGIVLGK SGLGVLNEDS
     ESIKLFTDIG KIYLMFVAGL EIDMVDFRRT RNRSLLYGSL TFAVPLLTGL AVGLTFGYSF
     NASVLLGSLF ASHTLLGYPI VQRLGIVRNQ AVMVTIGATI FTDIAALLVL AICISIHSGS
     FSPAGLVVQL VAIAVYSALV LIGFDWAGRE YFRRTGDEQS NQFLFVLLAV FLASVGSELI
     NVDKIVGAFL AGLAVNDVLG NSPVKEKVEF LGTTLFIPFF FIGIGLLLDL PAFLVTLTTL
     FPLVVAIVVG LILSKGVAAI LAQWKLGYTW VEGLTMWSLS IPQVAATLAA AVAGYQAVNA
     AGDRLVSETV LNTIIVLMLI TSIVGPLMTA KFAPKIPIPN TLSSLTEDLD DPEENGAVTL
     IPPKASTFTV LVPTQNPQTL SYLLEMGALI ARHESGVVIP LAIAKAPVHM DDPGLTSRLA
     RNELLLQQAT ELATNLKVDA HPALRIDDDV ARAISHTARE KNADLIIMGW SQQTLGLRAK
     LFGSTIDSVF WSAHCPVAVM RLLSDPRSFH RILFPIKNLT PQTLELFQFT QRLAETNGAI
     VTLLHVCPHN TSPQQVQAFK TEMERFLNQC RATADYPIKV ICHDDAAKVL VRVSHTFDLV
     VLRSFRRRSV GGVALGEVTD KILREITSSF VLFGDPYA